Synthesis and bioactivity ofO-ethyl phosphorodiamidates derived from quinazolin-4-ones and either amino acid esters or fatty amines

Ali, Hussein M.; Mostafa, Amany A.; El‐Zohry, Maher F.

doi:10.1002/(sici)1098-1071(1999)10:6<455::aid-hc3>3.0.co;2-9

Cited by 5 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[3] Incorporating the amino acid ester moiety into the phosphoryl diester shows the larvicidal activity. [4] Phosphorodiamidates offer various biological activities such as anticancer, antiviral, and anti-HIV. [5] They act as membrane-soluble prodrugs of the bioactive free nucleotides and anticancer agents, particularly against leukemia.…”

Section: Introductionmentioning

confidence: 99%

Efficient Protocol for the Synthesis of N‐Phosphorodiamidate Peptidomimetics

Hampasagarada Alavandimat,

Venkata Sureshbabu

2024

ChemistrySelect

View full text Add to dashboard Cite

Phosphoryl peptidomimetics represent a novel class of peptide analogs that have garnered attention due to their unique synthetic pathways. Employing a combination of Tf2O and pyridine, the amino acid phosphoryl diester transforms into a phosphorodiamidate compound. This conversion involves activating one of the ester moieties, yielding a good product. This protocol is characterized by its straightforward and comprehensive approach, making it a notable advancement in the chemistry of peptidomimetics.

show abstract

Section: Introductionmentioning

confidence: 99%

Efficient Protocol for the Synthesis of N‐Phosphorodiamidate Peptidomimetics

Hampasagarada Alavandimat,

Venkata Sureshbabu

2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

ChemInform Abstract: Synthesis and Bioactivity of O‐Ethyl Phosphorodiamidates Derived from Quinazolin‐4‐ones and Either Amino Acid Esters or Fatty Amines.

Ali¹,

Mostafa²,

El‐Zohry³

1999

ChemInform

View full text Add to dashboard Cite

Synthesis and Bioactivity of O-Ethyl Phosphorodiamidates Derived from Quinazolin-4-ones and Either Amino Acid Esters or FattyAmines.-The synthesis of several O-ethyl phosphorodiamidates derived from quinazolinones (II) and either fatty amines [→(V), 8 examples] or amino acid esters [→(VII), 9 examples] is described. The compounds show high insecticidal activity towards mosquito larvae. The highest activity is observed for compound (Vd) bearing both a nitro-substituent and a fatty amine moiety. Structure-activity relationships are discussed. -(ALI, HUSSEIN M.; MOSTAFA, AZZA A.; EL-ZOHRY, MAHER F.; Heteroat. Chem. 10 (1999) 6, 455-460; Dep. Agric. Biochem., Ain-Shams Univ., Cairo 11241, Egypt; EN)

show abstract

Quantitative structure-activity relationships (QSAR) of two series of O-aryl or N-aryl O-ethyl phosphoramidate and phosphorodiamidate fungicides incorporating amino acid ethyl esters

Ali

2000

Bull. Environ. Contam. Toxicol.

View full text Add to dashboard Cite

Synthesis and bioactivity ofO-ethyl phosphorodiamidates derived from quinazolin-4-ones and either amino acid esters or fatty amines

Cited by 5 publications

References 11 publications

Efficient Protocol for the Synthesis of N‐Phosphorodiamidate Peptidomimetics

Efficient Protocol for the Synthesis of N‐Phosphorodiamidate Peptidomimetics

ChemInform Abstract: Synthesis and Bioactivity of O‐Ethyl Phosphorodiamidates Derived from Quinazolin‐4‐ones and Either Amino Acid Esters or Fatty Amines.

Quantitative structure-activity relationships (QSAR) of two series of O-aryl or N-aryl O-ethyl phosphoramidate and phosphorodiamidate fungicides incorporating amino acid ethyl esters

Contact Info

Product

Resources

About