Quantitative structure-activity relationships (QSAR) of two series of O-aryl or N-aryl O-ethyl phosphoramidate and phosphorodiamidate fungicides incorporating amino acid ethyl esters

Efficient Method for the Synthesis of Diazaphospholidines: Toxicological Evaluation

“…We describe the inhibitory effect of phosphoramidate on Paramecium Aurelia (1a) and (1b), the unicellular ciliate, Paramecium (Peniculia, Oligohymenophorea), is one of the most studied protists. Considerable research has been conducted on its morphology, physiology, genetics, nuclear reorganization, phylogeny, and the concept of 'species' [12].…”

“…Organophosphorus compounds are ubiquitous in nature and find applications in the field of agriculture, medicine and industry. 1,2 Some organophosphorus compounds have been described in the literature as inhibitors of bacterial 3 , herbicides, insecticides, pesticides 4 , antifungal agents 5 , anti-HIV 6 , anti-cancer 7 , antiviral and anti-infla mmatory 8 . An important group of this class is phosphoramidate, which have been used in many reactions and synthesis of organic compounds.…”

Synthesis of Some Novel Thiadiazaphosphole, Oxazaphospholothiadiazaphosphole, Thiadiazaphosphinine, and Phosphonates Containing a 1,2,4‐Triazine Moiety

“…On the other hand, organophosphorus compounds have received much attention whether linear or cyclic. They were demonstrated to be pesticides , herbicides , antifungal , anti‐inflammatory , anti‐HIV , anticancer , and good cytotoxic on K562 and colo205 cancerous cells . These aforementioned reasons with our interest in organophosphorus chemistry encouraged us to synthesize new organophosphorus compounds incorporating 1,2,4‐triazinone moiety through reaction of 4‐amino‐6‐methyl‐3‐sulfanyl‐1,2,4‐triazin‐5(4 H )‐one ( 1 ) with different phosphorus reagents.…”