Synthesis and bioactivity of some fluorine‐containing benzoyl arylureas. Part I: Insecticidal‐acaricidal products in which the aryl group bears a trifluoromethyl‐substituted alkyl or alkenyl side chain

Abstract

This paper reports the synthesis and the biological activity of benzoyl arylureas in which the aryl group bears a trifluoromethyl‐substitiited alkyl or alkenyl side chain, R. The activity of these compounds has been evaluated on larvae of S. littoralis, A. aegypti, L. decemlineata and on the eggs of T. urticae. In general: (1) the optimum insecticidal activities are achieved when the substituents on the benzoyl moiety, R1, and R2, are 2,6‐difluoro, the substituents on the aryl moiety, R3, are 3,5‐dichloro and R1, is 4‐(CHC(CI)CF3); (2) the best acaricidal activity is shown when R1, is 2‐CI, R2, and R3, are hydrogen atoms and R1, is 4‐(CH2CH2CH(CI)CF3); (3) the best overall activity is displayed when R1, is 2‐CI, R2 is hydrogen, R3 is 3‐chloro and R1 is 4‐(CH2CH2CF3).

Synthesis and Insecticidal Activity of Heptafluoroisopropyl-Containing Benzoylphenylurea Structures

“…Aroyl isocyanates were synthesized from the corresponding aroyl amides according to the method in the literature . The target compounds were obtained by the reaction of heptafluoroisopropyl aniline with benzoyl isocyanates at room temperature in dried ethyl acetate .…”

Design, Synthesis, and Insecticidal Evaluation of New Benzoylureas Containing Isoxazoline and Isoxazole Group

“…All anhydrous solvents were dried and purified by standard techniques prior to use. 2,6-Difluorobenzoyl isocyanate was prepared by the method described in the literature. , Commercial insecticide Flucycloxuron and compound C were synthezied in our laboratory.…”

Design and Synthesis of Benzoylphenylureas with Fluorinated Substituents on the Aniline Ring as Insect Growth Regulators

“…All anhydrous solvents were dried and purified by standard techniques prior to use. 2,6-Difluorobenzoyl isocyanate was prepared according to the method of the literature …”