Synthesis and Bioactivity of New Phosphorylated R,R’-substituted Sulfoximines

Abstract

R,R’-disubstituted sulfoximines were phosphorylated with O,O–diethylchloro phosphate and phosphorothionate to obtain new organophosphorus compounds. After purification they were characterized by GC-MS and 1H-NMR. The toxicity of the synthesized O,O-diethyl N-(R,R’-disubstituted sulfoximine) phosphoro-amidothionates was assayed on Musca domestica. It was found that the methyl phenyl derivative was the most toxic compound, followed by the dipropyl and dibutyl derivatives. The dihexyl compound was the less toxic of all the assayed compounds, being one hundred times less toxic than a paraoxon standard The anticholinesterasic activity of the corresponding phosphoramidates was assayed on homogenates of house flies’ heads, giving values similar to paraoxon for the methyl phenyl derivative.

Cross-Hetero-Dehydrogenative Coupling Reaction of Phosphites: A Catalytic Metal-Free Phosphorylation of Amines and Alcohols

“…This versatile method for successful phosphorylation of amines and alcohols to obtain a wide range of phosphoramidates and phosphate esters has led to an investigation to examine the scope of phosphorylation of sulfoximines, which are potential insecticides . Therefore, we performed a preliminary study on phosphorylation of sulfoximines under optimal conditions that have been adopted for amines and alcohols.…”

Longevity and breeding records of ibises and spoonbills Threskiornithidae: in captivity

“…We have not been able to locate any records indicating that this species has ever been kept in zoological institutions. (Reinhard & Blaszkiewitz, 1988). Several Brazilian zoos have also kept this species in recent years and a possible first captive breeding was achieved at Brazilia Zoo where a single chick was successfully bred in 1992 (Anon., 1993).…”