Synthesis and bactericidal activities of novel pyrazole-1-carbothioamide derivatives

Abstract

4-(2-Hydroxy-phenyl)-but-3-en-2-one (1) was prepared via condensation of salicylaldehyde with acetone, and then reaction of the ketone 1 with thiosemicarbazide was accompanied by cyclization to give substituted pyrazole (2). Seven new 5-(2-hydroxy-phenyl)-3-methyl-4,5-dihydropyrazole-1-carbothioamide derivatives (3a−3g) were synthesized by the acylation of 2 and characterized by means of elemental analysis, infrared (IR), and 1 H nuclear magnetic resonance (NMR). The compounds 3c, 3d, and 3g showed certain bactericidal activity against E. coli; while compound 3g showed certain bactericidal activity against P. vulgaris.

Synthesis and fungicidal activity of novel 3,5-diarylpyrazole derivatives

“…However, little attention has been paid to the synthesis of pyrazole bearing 3,5-diphenyl moiety. In our previous work, we reported that lots of 5-phenyl-pyrazole derivatives showed fungicidal activities [7][8][9][10][11][12][13][14][15][16]. Motivated by the aforementioned findings, we anticipate that the diaryl-4,5-dihydropyrazoles would exhibit antimicrobial activity.…”