Abstract:This review surveys the structural characterization, synthetic methods, chemical transformations and mechanisms of methyleneaziridines, especially the advances achieved over the past decade.
“…The electrophilicity of carbon atoms on MAs ring inspired us to develop a convenient and efficient esterification in which carboxylic acids would be utilized as nucleophiles without preactivation (Scheme b). Because of our continuing interest in MAs, herein, we report a facile regioselective esterification of carboxylic acids with MAs under mild conditions without any non-green carboxyl activation strategy. This process efficiently provides two types of carboxylate esters in good yields via a solvent-controlled switch of selectivity between the sp 2 and sp 3 carbon nucleophilic reaction to MAs.…”
Herein, we report a convenient solvent-controlled regioselective
esterification to access two types of carboxylate esters without any
additive or non-green activation strategy. In this transformation,
2-methyleneaziridines served as an ester reagent, providing two alternative
electrophilic carbon centers. Notably, this protocol is suitable for
some structure-complicated clinical molecules with a carboxylic acid
group, presenting remarkable application potential.
“…The electrophilicity of carbon atoms on MAs ring inspired us to develop a convenient and efficient esterification in which carboxylic acids would be utilized as nucleophiles without preactivation (Scheme b). Because of our continuing interest in MAs, herein, we report a facile regioselective esterification of carboxylic acids with MAs under mild conditions without any non-green carboxyl activation strategy. This process efficiently provides two types of carboxylate esters in good yields via a solvent-controlled switch of selectivity between the sp 2 and sp 3 carbon nucleophilic reaction to MAs.…”
Herein, we report a convenient solvent-controlled regioselective
esterification to access two types of carboxylate esters without any
additive or non-green activation strategy. In this transformation,
2-methyleneaziridines served as an ester reagent, providing two alternative
electrophilic carbon centers. Notably, this protocol is suitable for
some structure-complicated clinical molecules with a carboxylic acid
group, presenting remarkable application potential.
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