Synthesis and application of strawberry-like Fe 3 O 4 -Au nanoparticles as CT-MR dual-modality contrast agents in accurate detection of the progressive liver disease

Zhao, Hui; Liu, Sen; He, Jian; Pan, Chao; Li, Hui; Zhou, Zheng; Ding, Yin; Huo, Da; Hu, Yong

doi:10.1016/j.biomaterials.2015.02.019

Cited by 90 publications

(68 citation statements)

References 65 publications

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“…On the other hand, gold (Au) NPs, owning to the higher atomic number of Au than that of iodine for iodinated CT contrast agents (e.g., Omnipaque), have been explored as CT imaging agents2324. For accurate dual mode MR/CT imaging applications, Fe 3 O 4 /Au composite nanoparticles (CNPs) has been designed2526. For example, Cai et al .…”

mentioning

confidence: 99%

Multifunctional Fe3O4 @ Au core/shell nanostars: a unique platform for multimode imaging and photothermal therapy of tumors

Wang

et al. 2016

Sci Rep

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110

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We herein report the development of multifunctional folic acid (FA)-targeted Fe3O4 @ Au nanostars (NSs) for targeted multi-mode magnetic resonance (MR)/computed tomography (CT)/photoacoustic (PA) imaging and photothermal therapy (PTT) of tumors. In this present work, citric acid-stabilized Fe3O4/Ag composite nanoparticles prepared by a mild reduction route were utilized as seeds and exposed to the Au growth solution to induce the formation of Fe3O4 @ Au core/shell NSs. Followed by successive decoration of thiolated polyethyleneimine (PEI-SH), FA via a polyethylene glycol spacer, and acetylation of the residual PEI amines, multifunctional Fe3O4 @ Au NSs were formed. The designed multifunctional NSs possess excellent colloidal stability, good cytocompatibility in a given concentration range, and specific recognition to cancer cells overexpressing FA receptors. Due to co-existence of Fe3O4 core and star-shaped Au shell, the NSs can be used for MR and CT imaging of tumors, respectively. Likewise, the near infrared plasmonic absorption feature also enables the NSs to be used for PA imaging and PTT of tumors. Our study clearly demonstrates a unique theranostic nanoplatform that can be used for high performance multi-mode imaging-guided PTT of tumors, which may be extendable for theranostics of different diseases in translational medicine.

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mentioning

confidence: 99%

Multifunctional Fe3O4 @ Au core/shell nanostars: a unique platform for multimode imaging and photothermal therapy of tumors

Wang

et al. 2016

Sci Rep

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110

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“…The synthesized particles were intended to accumulate in Kupffer cells and were investigated in vivo for their diagnostic potential of three stages of liver diseases: fatty liver, cirrhotic liver, and HCC. In the case of HCC, particles acted as a negative contrast by providing contrast to the liver parenchyma but not the tumor location [77].…”

Section: Macrophage Targeted Formulationsmentioning

confidence: 99%

“…The aforementioned study by Zhao et al first synthesized Fe 3 O 4 particles by coprecipitation, capped with mercaptosuccinic acid (DMSA) before AuNP were reduced onto their surface. Both MR and CT contrast in the liver parenchyma was at a peak 30 minutes postinjection and was still enhanced after 6 hours, although significance was not assessed [77].…”

Section: Gold Nanoparticle-based Contrast Agents For Magneticmentioning

confidence: 99%

Gold Nanoparticles as X-Ray, CT, and Multimodal Imaging Contrast Agents: Formulation, Targeting, and Methodology

Mahan

Doiron

2018

Journal of Nanomaterials

102

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Computed tomography (CT) is among the most popular medical imaging modalities due to its high resolution images, fast scan time, low cost, and compatibility with all patients. CT scans of soft tissues require the localization of imaging contrast agents (CA) to create contrast, revealing anatomic information. Gold nanoparticles (AuNP) have attracted interest recently for their use as CT CA due to their high X-ray attenuation, simple surface chemistry, and biocompatibility. Targeting molecules may be attached to the particles to allow for the targeting of specific cell types and disease states. AuNP can also be readily designed to incorporate other imaging contrast agents such as rare earth metals and dyes. This review summarizes the current state-of-the-art knowledge in the field of AuNP used as X-ray and multimodal contrast agents. Primary research is analyzed through the lens of structure-propertyfunction to best explain the design of a particle for a given application. Design specification of particles includes size, shape, surface functionalization, composition, circulation time, and component synergy. Key considerations include delivery of a CA payload to the site of interest, nontoxicity of particle components, and contrast enhancement compared to the surrounding tissue. Examples from literature are included to illustrate the strategies used to address design considerations.

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“…In detail, owing to lack of sufficient understanding and rational cost-to-benefit analysis for each imaging approach, previous organizations of different imaging modalities are usually arbitrary, [13][14][15] e.g., Liu et al prepared multifunctional NaYF 4 :Yb, Er@mSiO 2 @Fe 3 O 4 -PEG nanoparticles for UCL/MR bioimaging, 15 but SiO 2 coating impeded light transmission and resulted in reduced fluorescence intensity in comparison to free UCNP nanoparticles, 16 In this report, with in-depth understanding of each operation principle, ultrasound, CT and MR are selected to acquire the complete information of caners via exerting their personal advantages. 18,19 Differing from the previous design strategy of CAs, namely simple assembly of building blocks, a novel design strategy, marriage of structure and composition designs has been developed.…”

mentioning

confidence: 99%

Marriage Strategy of Structure and Composition Designs for Intensifying Ultrasound & MR & CT Trimodal Contrast Imaging

Zhang

Chen

et al. 2015

ACS Appl. Mater. Interfaces

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Despite great efforts having been devoted to the design of multimodal imaging probe, almost all design principles of nanotheranostic agents subordinate to simple assemblies of building blocks, resulting in complex preparation process and discounted ability, that is, 1 + 1 < 2. In this report, a novel design strategy, marriage of structure design and composition design that can maximize imaging ability of each building block, ultimately achieving 1 + 1 ≥ 2, has been established. Moreover, a high-efficient ultrasound (US) & MR & CT trimodal contrast agent acts as model to instantiate this design strategy, wherein nanoparticles-induced nonlinear scattering and rattle-type structure-induced double scattering enhancing US imaging, and uniform distribution of Mn(2+) paramagentic centers and "core-satellite" structure of Au atoms favoring enhanced MR imaging and CT imaging, respectively have been validated, achieving optimization of structure design. Importantly, the selected components, silica, Au and MnO are endowed with excellent biocompatibility, displaying the marriage strategy of composition design with aforementioned structure optimization. In in vivo evaluations, such a biocompatible trimodal probe is demonstrated of excellent performance in intensifying CT, MR and US imaging in vivo, especially after positively charged modification by PEI promoting more probes retained in tumor. More importantly, as a universal design strategy, the involved principles in constructing such a US&MR&CT trimodal imaging probe promise great potentials in guiding designs of other materials-based multimodal imaging probe.

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Synthesis and application of strawberry-like Fe 3 O 4 -Au nanoparticles as CT-MR dual-modality contrast agents in accurate detection of the progressive liver disease

Cited by 90 publications

References 65 publications

Multifunctional Fe3O4 @ Au core/shell nanostars: a unique platform for multimode imaging and photothermal therapy of tumors

Multifunctional Fe3O4 @ Au core/shell nanostars: a unique platform for multimode imaging and photothermal therapy of tumors

Gold Nanoparticles as X-Ray, CT, and Multimodal Imaging Contrast Agents: Formulation, Targeting, and Methodology

Marriage Strategy of Structure and Composition Designs for Intensifying Ultrasound & MR & CT Trimodal Contrast Imaging

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