Synthesis and Antiviral Screening of Some Thieno[2,3-d]Pyrimidine Nucleosides

Abstract

Some cyclic and acyclic nucleosides of thieno[2,3-d]-pyrimidine derivatives were synthesized via the reaction of compounds 1 and 2 or 3 and 4 with 2-chloroethyl methyl ether or 2,3,4, 6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide. Nucleosides 9, 10, 15, and 16 were tested as antiviral agents against herpes simplex virus type-1 (HSV-1) and hepatitis-A virus (HAV). Compound 15 showed the highest effect on HSV-1 than the other three compounds, while the four tested compounds did not show any activity against HAV.

Synthesis, characterization, and antimicrobial evaluation of novel 4‐pyrrol‐1‐yl‐5,6,7,8‐tetrahydro‐pyrido[4′,3′:4,5] thieno[2,3‐d]pyrimidine derivatives

“…Thienopyrimidine possess various physiological and biological properties, and thus, find important use in medicine. According to recent literature survey, thienopyrimidine have been found to have antibacterial [15], antiviral [16], anticancer [17][18][19], analgesic [20], and antimalarial [21] activities. Though many synthetic strategies have been reported for the preparation of thienopyrimidine derivatives, most of them include use of expensive, commercially nonavailable or hazardous reagents, drastic reaction conditions, longer reaction time and difficult work-up [22][23][24][25][26][27].…”

Design, Synthesis, and Molecular Docking of Novel Pyrrolooxazepinediol Derivatives with Anti‐Influenza Neuraminidase Activity

“…The crude material was purified by column chromatography on silica gel (dichloromethane/methanol/aq. NH 3 In vitro anti-influenza virus assay: The antiviral activity of the target compounds was determined against low pathogenic reassortant avian influenza virus (rH5N1) [27] from the National Research Center (NRC) using the CPE assay as previously described [28,29] with oseltamivir phosphate as a control. Stock solutions of the test compounds were prepared in DMSO at a concentration of 10 mg/mL.…”

Synthesis and antimicrobial activity of some new thienopyrimidine derivatives

“…Pyrimidine and thienopyrimidine derivatives display a broad variety of biological activities, such as anticancer, [1][2][3][4][5][6] antiviral, [7][8][9] antitumor, [10][11][12][13][14][15] anti-inflammatory, 16,17 antimicrobial, [18][19] antimalarial 20 and antioxidant activities. 21,22 Also thienopyrimidines have long been the subject of chemical and biological research.…”