A series of novel 7-alkyl/aryl sulfonyl-4-pyrrol-1-yl-5,6,7,8-tetrahydro-pyrido[4 0 ,3 0 :4,5]thieno[2,3-d] pyrimidine 6 were synthesized for evaluation of their antibacterial and antifungal activity. The structures were determined by IR, NMR, mass spectroscopy, and elemental analysis. They were screened for activities against bacterial and fungal strains.
Triazole skeleton is ubiquitous in pharmaceutically important compounds. A novel series of indoline‐containing triazole with different amides are described, which exhibit antibacterial and antifungal activities. The chemical synthesis strategies used, the complete characterization of the compounds, their in vitro screening, and the promising activity as reflected in the MIC values are reported. J. Heterocyclic Chem., (2010).
A series of 2-aminothiazoles derivatives have been synthesized and tested for in vitro antibacterial activity on different microorganisms. Syntheses have been carried out following simple methodology in excellent isolated yields. The structure and purity of the original compounds were confirmed by IR, NMR, Mass spectroscopy, and elemental analysis. All compounds were tested for antibacterial activity against S. aureus, S. pyogenes, E. coli, P. aeruginosa, S. typhi and V. parahaemolyticus. These preliminary results indicate that some of compounds are exhibiting good activity.
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