Synthesis and Antiviral Evaluation of Isatin Ribonucleosides

Oliveira, Mara Rita P. de; Torres, Javier Rodríguez; Garden, Simon J.; Santos, Carla V.B.; Alves, Thatyana R.; Pinto, Ângelo C.; Pereira, Helena de Souza; Ferreira, Luiz Roberto Leao; Moussatché, Nissin; Frugulhetti, Izabel Christina de P. P.; Ferreira, Vı́tor F.; Souza, Maria Cecília B. V. de

doi:10.1081/ncn-120016510

Cited by 8 publications

(2 citation statements)

References 19 publications

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“…Based on the potential therapeutic properties of nucleoside derivatives as effective medications in a vast range of viral diseases [ 86 ], a series of novel substituted isatin ribonucleosides [ 31 ] (Fig. 36 ) was synthesized by de Oliveira et al [ 87 ]. Next, these compounds were evaluated for antiviral activity on HSV-1-infected cells.…”

Section: Anti-herpetic Isatin Derivativesmentioning

confidence: 99%

Isatin derivatives as broad-spectrum antiviral agents: the current landscape

et al. 2022

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In recent decades, several viruses have resulted in large outbreaks with serious health, economic and social consequences. The current unprecedented outbreak of the new coronavirus, SARS-COV-2, necessitates intensive efforts for delivering effective therapies to eradicate such a deadly virus. Isatin is an opulent heterocycle that has been proven to provide tremendous opportunities in the area of drug discovery. Over the last fifty years, suitably functionalized isatin has shown remarkable and broad-spectrum antiviral properties. The review herein is an attempt to compile all of the reported information about the antiviral activity of isatin derivatives with an emphasis on their structure-activity relationships (SARs) along with mechanistic and molecular modeling studies. In this regard, we are confident that the review will afford the scientific community a valuable platform to generate more potent and cost-effective antiviral therapies based on isatin templates.

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Section: Anti-herpetic Isatin Derivativesmentioning

confidence: 99%

Isatin derivatives as broad-spectrum antiviral agents: the current landscape

et al. 2022

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“…Heterocyclic compounds with an isatin nucleus have assorted biological merits, including anti-inflammatory, analgesic [1][2][3][4][5], anticancer [6][7][8][9][10][11], antiglycation [12], antimalarial [13][14][15][16][17], antioxidant [18][19][20][21], anthelmintic [22], and antianxiety activities [23]. Moreover, they work as anticonvulsants [24,25], anti-HIV [26][27][28], antiviral [29], antibacterial [30][31][32][33][34], anti-fungal [35], and anti-tubercular agents [36][37][38][39]. Isatin derivatives also have various industrial applications, they are used as corrosion inhibitors [40][41][42], fluorescent sensors [43][44][45][46], and also in the dye industry [47,…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Isatin Derivatives as Antibacterial Inhibitors

Badrey

Essawy

Hassan

et al. 2023

Labyrinth: Fayoum Journal of Science and Interdisciplinary Stud

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Herein, 2'-amino-6'-(ethylthio)-2-oxo-1'H-spiro[indoline-3,4'-pyridine]-3',5'-dicarbo-nitrile I and 2-(2-oxoindolin-3ylidene)hydrazine-1-carbox-imidamide II were served as prestarting intermediates for the production of polyfunctional substituted heterocycles like; pyrazole, pyridine, imidazole, and pyrimidine. Subsequently, representative chemicals of the manufactured series were verified and assessed as antibacterial inhibitors. Spiro-indoline pyridine I was prepared to be used as a beginning material for manufacturing assorted novel heterocyclic compounds containing an isatin moiety. Derivative I was obtained via the reaction of isatylidene malononitrile with malononitrile and ethyl thiol in the presence of ammonium acetate. The starting compound I was permitted to combine with carbon disulfide in boiling pyridine to afford the carbamodithioic acid derivative III. Also, the reaction of compound I with triethyl orthoformate, maleic anhydride, dimethylformamide, dimethyl acetal, hydrazine hydrate, and diethyl malonate yielded compounds IV, V, VI, VII, and VIII respectively. Moreover, the reaction of the ketonic carbonyl group of isatin with aminoguanidine salt in aqueous alcohol when there was a catalytic amount of sodium bicarbonate yielded compound II. Likewise, carboximidamide derivative II reacted with active methylene compounds such as malononitrile and its derivatives; namely, ethoxy methylene malononitrile and chloroacetonitrile to afford compounds XI, XII, and IX, respectively. On the other hand, compound II interaction with dimethyl acetylenedicarboxylate allowed a heterocyclic imidazole derivative to be obtained.

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