Synthesis and antiviral activity of antipyrine derivatives

Synthesis of 4-aminoantipyrine derived Schiff bases and their evaluation for antibacterial, cytotoxic and free radical scavenging activity

“…Schiff bases synthesized from aromatic reactants have variety of applications in biological, inorganic and analytical chemistry (Kabak et al, 2000). 4-aminoantipyrine is a pyrazolone derivative, it has shown wide range of biological activities such as antimicrobial activity (Awad et al, 2007), analgesic (Burdulene et al, 1999), antiviral (Evstropov et al, 1992) and also used as precursors in the synthesis of bioactive compounds i.e. β-lactams (Raman et al, 2009).…”

Synthesis and characterization of novel pyrazolone derivatives

“…During the discovery of pyrazolone, they were only known as NSAIDs [2] but, since year 2000, they play versatile role in several complications like cerebral ischemia and cardiovascular diseases [3]. The chemistry of pyrazolone has gained increasing attention due to its diverse pharmacological properties [4] such as cytotoxic [5,6], anti-inflammatory [7], antimicrobial [8,9], antioxidant [10], antiviral [11], oral hypoglycemic activity [12] and analgesic [13,14]. Pyrazolones are believed to be involved in various biochemical and physiological reactions and thus scientific research programs are continually improvising synthetic techniques to prepare numerous pyrazolone derivatives.…”

Untitled

“…Similarly, Pyrazolone and its derivatives such as 4-aminoantipyrine have shown various biological applications such as anti-inflammatory 15 , analgesic 16 , antiviral 17 , antipyretic and antimicrobial activity 18 . The versatile applications of 4-aminoantipyrine have given interest to design and synthesize novel derivatives using combinatorial chemistry 19 .…”