Synthesis and characterization of novel pyrazolone derivatives

Abstract

KEYWORDSThe reactivity of hydrogen atoms at C-4 of pyrazolone 3 towards condensation reactions was studied by its reaction with p-anisaldehyde, malononitrile and/or ethyl acetoacetate in the presence of ammonium acetate and/or piperidine, glucose, phenyl isothiocyanate, 2-amino thiazole and aniline to afford compounds 4-6, 13, 15, 17 and 18, respectively. Reaction of amino carbonitrile 4 with ammonium thiocyanate, and formamide afforded compound 7 and pyrazolo [3,4-b]

Insights into 4,4′‐Arylmethylene‐Bis‐1 H ‐Pyrazol‐5‐Ols Scaffolds: Various Synthetic Routes and Their Applications

“…This method was almost better than traditional heating methods because it took less time, gave a better yield, and was more environmental friendly(Scheme 6). [39] Scheme 3. Synthesis of (3) using humic acid, acetic acids, (CLE) and SBSSA catalyst.…”

“…This method was almost better than traditional heating methods because it took less time, gave a better yield, and was more environmental friendly(Scheme 6). [39] …”

Insights into 4,4′‐Arylmethylene‐Bis‐1 H ‐Pyrazol‐5‐Ols Scaffolds: Various Synthetic Routes and Their Applications

“…This method was almost better than traditional heating methods because it took less time, gave a better yield, and was more environmental friendly(Scheme 6). [39] Scheme 3. Synthesis of (3) using humic acid, acetic acids, (CLE) and SBSSA catalyst.…”

“…This method was almost better than traditional heating methods because it took less time, gave a better yield, and was more environmental friendly(Scheme 6). [39] …”

1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications

“…There are some examples of the 1,3-NCC-dinucleophile being generated in situ. Hamama et al and Marzouk et al used 3-pyrazolones that reacted with ammonia to generate the 3-aminopyrazole ring [ 91 , 92 ].…”

Thermal Degradation Kinetics of a Novel Pyrazole Based Copolymer [poly(1,3-diphenyl-1H-pyrazol-5-yl methacrylate-co-styrene)]

“…Heteroaromatik moleküller sınıfının önemli bir üyesi olan pirazoller, beşli halka sistemlerinde iki adet azot atomu barındırmaktadır. Bu beş üyeli laktam halkası, yapısında bir ketonik grup ve iki azot atomu içerdiğinde yapı pirazolon olarak tanımlanırken; pirazolon halkasındaki tautomerleşme sonucunda ise yapı pirazolol şeklinde adlandırılmaktadır (Marzouk et al 2014, Kumar et al 2012. Pirazol ya da pirazolon bileşikleri üzerinde yapılan çalışmalar özellikle bu bileşiklerin geniş farmakolojik özellikleri nedeniyle son zamanlarda önem kazanmıştır (Karrouchi et al 2018).…”

Insights into 4,4′‐Arylmethylene‐Bis‐1 H ‐Pyrazol‐5‐Ols Scaffolds: Various Synthetic Routes and Their Applications

“…This method was almost better than traditional heating methods because it took less time, gave a better yield, and was more environmental friendly(Scheme 6). [39] Scheme 3. Synthesis of (3) using humic acid, acetic acids, (CLE) and SBSSA catalyst.…”

“…This method was almost better than traditional heating methods because it took less time, gave a better yield, and was more environmental friendly(Scheme 6). [39] …”

1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications

“…There are some examples of the 1,3-NCC-dinucleophile being generated in situ. Hamama et al and Marzouk et al used 3-pyrazolones that reacted with ammonia to generate the 3-aminopyrazole ring [ 91 , 92 ].…”

Thermal Degradation Kinetics of a Novel Pyrazole Based Copolymer [poly(1,3-diphenyl-1H-pyrazol-5-yl methacrylate-co-styrene)]

“…Heteroaromatik moleküller sınıfının önemli bir üyesi olan pirazoller, beşli halka sistemlerinde iki adet azot atomu barındırmaktadır. Bu beş üyeli laktam halkası, yapısında bir ketonik grup ve iki azot atomu içerdiğinde yapı pirazolon olarak tanımlanırken; pirazolon halkasındaki tautomerleşme sonucunda ise yapı pirazolol şeklinde adlandırılmaktadır (Marzouk et al 2014, Kumar et al 2012. Pirazol ya da pirazolon bileşikleri üzerinde yapılan çalışmalar özellikle bu bileşiklerin geniş farmakolojik özellikleri nedeniyle son zamanlarda önem kazanmıştır (Karrouchi et al 2018).…”

Insights into 4,4′‐Arylmethylene‐Bis‐1 H ‐Pyrazol‐5‐Ols Scaffolds: Various Synthetic Routes and Their Applications

“…This method was almost better than traditional heating methods because it took less time, gave a better yield, and was more environmental friendly(Scheme 6). [39] Scheme 3. Synthesis of (3) using humic acid, acetic acids, (CLE) and SBSSA catalyst.…”

“…This method was almost better than traditional heating methods because it took less time, gave a better yield, and was more environmental friendly(Scheme 6). [39] …”

1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications

“…There are some examples of the 1,3-NCC-dinucleophile being generated in situ. Hamama et al and Marzouk et al used 3-pyrazolones that reacted with ammonia to generate the 3-aminopyrazole ring [ 91 , 92 ].…”

Thermal Degradation Kinetics of a Novel Pyrazole Based Copolymer [poly(1,3-diphenyl-1H-pyrazol-5-yl methacrylate-co-styrene)]

“…Heteroaromatik moleküller sınıfının önemli bir üyesi olan pirazoller, beşli halka sistemlerinde iki adet azot atomu barındırmaktadır. Bu beş üyeli laktam halkası, yapısında bir ketonik grup ve iki azot atomu içerdiğinde yapı pirazolon olarak tanımlanırken; pirazolon halkasındaki tautomerleşme sonucunda ise yapı pirazolol şeklinde adlandırılmaktadır (Marzouk et al 2014, Kumar et al 2012. Pirazol ya da pirazolon bileşikleri üzerinde yapılan çalışmalar özellikle bu bileşiklerin geniş farmakolojik özellikleri nedeniyle son zamanlarda önem kazanmıştır (Karrouchi et al 2018).…”