Synthesis and Antiviral Activity of Novel Thieno[2,3-d]pyrimidine Hydrazones and Their C-Nucleosides

Khattab, Reham R.; Hassan, Allam A.; Kutkat, Omnia; Abuzeid, Khadiga M.; Hassan, Nasser A.

doi:10.1134/s1070363219080267

Cited by 13 publications

(12 citation statements)

References 20 publications

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“…Cyclization of (Va, b)was achieved uponrefluxing with FeCl 3 giving thienotriazolopyrimidine derivatives (VIa, b).The probable FeCl 3 -promoted cyclization mechanism was reported in our previous work [22]. The IR and 1 H NMR of compounds(VIa, b) displayed the absence of the signal attributed to (NH) proton.…”

Section: Resultssupporting

confidence: 52%

“…Treatment of compounds (VIIIa, b)with acetic anhydride in the presence of pyridine at ambient temperature provided per-O-acetylated sugar hydrazones (IXa, b). The acetylation occur only to the hydroxyl groups of the sugar residue without N-acetylation of the hydrazone residue [22,[25][26][27][28]. The IR of compounds (IXa, b) showed signals for ester carbonyls groups at 1747 and 1743 cm -1 , respectively and absorption bands due to (NH) group at 3434 and 3436 cm -1 with the disappearance of signals for hydroxyl groups.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore thienopyrimi-dine nucleosides regarded as antiviral agents [19,20] and as anti-cancer [21]. Based on the aforementioned and expansion of our concern toward the chemistry of thieno[2, 3-d]pyrimidine [21][22][23][24], we plan to synthesize some novel thienopyrimidine moiety fused with a triazole ring as well as their acyclo C-nucleoside derivatives and testing their anti-cancer activity.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Anticancer Activity Evaluation of Some Thienopyrimidine Derivatives

et al. 2021

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The current study focused on effective and straightforward routes for preparing a new series of thieno [2,3-d]pyrimidine derivatives in addition to their acyclo nucleosides analogue. The chemical structures of the synthesized products have been elucidated through diverse spectroscopy analyses such as (IR, NMR, MS, and elemental analyses). Some selected thienopyrimidine derivatives were investigated for their anticancer activity against two human cancer cell lines (HepG-2 and MCF-7). The results revealed that compounds 3-ethyl-2-hydrazineyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno [2,3-d]pyrimidin-4-oneand3-ethyl-2-(2-glucozylidenehydrazineyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno [2,3-d]pyrimidin-4-one showed the most potent anticancer activity.

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Section: Resultssupporting

confidence: 52%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis and Anticancer Activity Evaluation of Some Thienopyrimidine Derivatives

et al. 2021

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“…Reported thienopyrimidines, I and II displayed promising anticancer and kinase inhibitory activity against EGFR 26,27 (Figure 1). Furthermore, compounds possessing thienopyrimidine motif were reported with interesting bioactivities such as anticancer 28,29 , antiviral 30 , antibacterial 31 , and anti-inflammatory 32 activities. Different glycosyl heterocycles have been synthesised and revealed potential anticancer and enzyme inhibition activities providing essential roles in biological systems, and glycosides possessing the 1,2,3-triazole core, e.g.…”

Section: Introductionmentioning

confidence: 99%

Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR

Khattab

Alshamari²,

Hassan

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…The multicomponent reactions are essential in pharmaceutical preparations and organic conversions. Furthermore, nucleosides have various pharmacological and biological applications like antiviral [43], anticancer [44] and antimicrobial activities [45]. Selenium (Se) is an essential trace element.…”

Section: Introductionmentioning

confidence: 99%

Novel Sono-synthesized Triazole Derivatives Conjugated with Selenium Nanoparticles for cancer treatment

Khattab

swelm²,

Khalil³

et al. 2021

Egypt. J. Chem.

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Green chemistry is among the important applied aspects to synthesize novel bioactive compounds. We aim to provide triazole derivatives using eco-friendly methods such as sonication technology. This procedure was performed by using natural catalysts such as natural citrus squeezes. Ultrasonic irradiation was employed in the presence of natural juices such as lemon or/and orange juice to synthesize triazole derivatives. The synthesized compounds were investigated using FTIR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental analysis. The cytotoxicity and in vitro anticancer evaluation of the synthesized triazole derivatives and the derivatives selenium nanoparticles have been assessed towards human liver cancer cell line (HEGP2) in addition to BALB/3T3 (murine fibroblast) normal cell line. Some compounds showed an active selectivity towards the human liver cancer cell line (HEGP2). However, they have no activity for the BALB/3T3 (murine fibroblast) normal cell line. Meanwhile, after evaluating the cytotoxicity of the synthesized compounds and in vitro anticancer activities, compounds 12a, 12b, 13a, 13b were selected to contribute in synthesizing in-situ selenium nanoparticles (SeNPs). The results showed a significant in vitro antiproliferative activity of the synthesized compounds.

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Synthesis and Antiviral Activity of Novel Thieno[2,3-d]pyrimidine Hydrazones and Their C-Nucleosides

Cited by 13 publications

References 20 publications

Synthesis and Anticancer Activity Evaluation of Some Thienopyrimidine Derivatives

Synthesis and Anticancer Activity Evaluation of Some Thienopyrimidine Derivatives

Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR

Novel Sono-synthesized Triazole Derivatives Conjugated with Selenium Nanoparticles for cancer treatment

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