Synthesis and Antiviral Activity of 3-(β-D-Ribofuranosyl)-1,2,4-oxadiazole-5-carboxamide

Abstract

3-(beta-D-Ribofuranosyl)-1,2,4-oxadiazole-5-carboxamide (5) was prepared by condensation reaction of amidoxime 6 with monoethyl oxaloyl chloride followed by reaction with ammonia. The compound 5, however, did not exhibit any significant activity against herpes simplex virus type-I (HSV-I) and semliki forest virus (SFV).

In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies of substituted 1,2,4-oxadiazole analogues against Mycobacterium tuberculosis

“…These clinical success in parallel gave an impetus to the synthetic chemists to design innovative strategies for the economic, ecofriendly and rapid synthesis of 1,2,4-oxadiazole chemical libraries to accelerate the drug discovery process 32 , 33 . In the past 40 years, 1,2,4-oxadiazole scaffold has been extensively investigated for diverse biological activities 34 including anti-inflammatory 35 , 36 , analgesic 37 , anaesthetic 38 , anthelmintic 39 , antiallergic 40 , anti-Alzheimer 41 , antibacterial 42 , 43 , anticancer 44–46 , anticonvulsant 47 , 48 , antidepressant 49 , antifungal 50 , anti-HIV 51 , antiparasitic 52 , antiplatelet and antithrombotic 53 , anti-tubercular 54 , antitussive 55 , antiviral 56 , 57 , insecticidal 58 , monoamine oxidase inhibition 59 , muscarinic receptor agonists 60 , selective G-protein bile acid receptor 1 (GPBAR1) agonists 61 and selective H 3 receptor antagonists 62 activities.…”

Vinyl-1,2,4-oxadiazoles Behave as Nucleophilic Partners in Morita–Baylis–Hillman Reactions

“…Its metabolic profile associated with its ability to act as hydrogen bond acceptor allows its use as bioisostere of esters and amides . Molecules bearing this heterocyclic pattern also display great diversity of biological activities, such as antitumor, antibacterial, antiviral, , anti-inflammatory, insecticidal, antiparasitic, , and muscarinic receptors agonist …”

SYNTHESIS AND ANTIMICROBIAL SCREENING OF SOME NEW 4-IMINO-3,5,7-TRISUBSTITUTED PYRIDO[2,3-d]PYRIMIDINES AND THEIR RIBOFURANOSIDES AS POTENTIAL CHEMOTHERAPEUTIC AGENTS

“…antibacterial, 1,2 anticancer, 3−4 antiulcer, 5 anticonvulsant, 6,7 antihypertensive, 8 antitumor, 9 antifungal, 10,11 antiAIDS, 12 antiherpes, 13 antiviral, 14 and antineuplastic. 15 With a recent patent, e.g., Martin et al 16 have demostrated that pyrido [2,3-d]pyrimidines are active against P 38 kinase; Reinhard et al 17 have synthesized pyrido [2,3-d] pyrimidine derivatives as analogs of the antifolates methotrexate.…”