Synthesis and antiviral activity of novel pyrazole derivatives containing oxime esters group

Microwave-Assisted Synthesis and Cytotoxicity Evaluation of Some Novel Pyrazole Containing Imidiazole, Pyrazole, Oxazole, Thiadiazole and Benzochromene derivatives

“…As a part of an ongoing development of efficient protocols for the preparation of biologically active heterocycles from common intermediates (1). 4-Disubstituted imidiazolyl-3-methyl-1-phenyl-1H-pyrazole derivatives 8 were synthesized in high yield under microwave irradiation [38] by the reaction of 1,2-diketones such as 1,2-difuran-2-yl-ethane-1,2-dione (7a), 1,2-diphenyl-ethane-1,2-dione (7b) and 3-methyl-1-phenyl-1H-pyrazole-4-carboxaldehyde (1) in the presence of ammonium acetate (Table 1). Furthermore, treatment of (1) The most probable mechanism of the resulting compound 8, which is shown in Scheme 3.…”

“…So it clearly underlies the urgent need for developing novel chemotherapeutic agents with more potent antitumor activities. Recently, pyrazole derivatives have attracted a great attention due to their several chemicals and pharmacological importance [1][2][3]. Moreover, many pyrazole derivatives exhibit a wide range of therapeutic activities including anticonvulsant [4], analgesic, anti-inflammatory [5][6][7], antimicrobial [8], anticoagulant activity [9], antioxidant [10], antiamoebic [11,12], Antidepressant [13], antihyperglycemic [14], antihistaminic [15], anti-viral [16], anti-HIV [17], and anticancer [18][19][20][21][22].…”

Chemical Outbreak for Tobacco Mosaic Virus Control

“…Pathogen related (PR) genes such as PR-1, which is related to the salicylic acid-mediated signal transduction pathway, is positively regulated by pyrazole derivative (Ouyang et al, 2008). Treatment was shown to increase the activity of peroxidase and superoxide dismutase.…”

“…The search for TMV treatments has not stopped although no virus-curative agrochemicals are available in the market, except for the antiviral agent ningnanmycin (NNM), which seems to lead to curative rates of 30-60% (Ouyang et al, 2008). Unfortunately these results mainly refer to lab tests (in vitro or in vivo tests via the half leaf method) and more data on open-field applications are needded, thus the search for new compounds continues.…”

Synthesis, Characterization and Antimicrobial Evaluation of Substituted 1,2,4-Triazole Thiones Containing Pyrazole Moiety

“…These days, the fusion of medicinally important heterocyclic rings to prospective pharmaceutical candidates is a major strategy to achieve greater activity and wider medicinal spectrum. Keeping this in view, the authors herewith report the synthesis and pharmacological evaluation of 1,2,4-triazole thiones fused with pyrazole, an another medicinally important heterocyclic ring system having broad pharmacological spectrum [17][18][19][20][21][22][23]. A number of compounds containing diverse pharmacological importance is reported from these laboratories [24,25] Material and Method All Chemicals and regents were procured from Ranbaxy Laboratories Ltd, Chemical Division, India.…”