Synthesis and antitumor studies of novel benzopyrano-1,2,3-selenadiazole and spiro[benzopyrano]-1,3,4-thiadiazoline derivatives

Synthesis and Crystal Structures of Two New Oxaspirocyclic Compounds

“…Also, it has been found that the selectivities and activities of spiro compounds will be stronger by inducting an oxygen atom. The presence of oxaspirocyclic compounds in various natural products has also emerged, increasing interest due to their important biological activities, such as antimicrobial [9,10], antitumor [11] ,antiproliferative [12], antiviral [13], antiplasmodial [14] and antihistamic [15] activity etc. Based on these reasons, our group began to synthesize various oxaspirocyclic compounds and study their chemical properties [16][17][18][19].…”

TiO2 Nanoparticles Immobilized on Carbon Nanotubes: An Efficient Heterogeneous Catalyst in Cyclocondensation Reaction of Isatins with Malononitrile and 4‐Hydroxycoumarin or 3,4‐Methylenedioxyphenol under Mild Reaction Conditions

“…Due to the wide range of biological and medicinal activities the synthesis of spiro compounds has become a significant target over the past decade. 1 H ‐indole‐2,3‐diones (isatins) are important core structures, able to form a large number of both naturally occurring and synthetic spiroheterocycles and know to exhibit several biological activities like antiinflammatory, and laxative agents, antibacterial, antimicrobial, antimalaria, antitumor, antitubercular, and anti‐HIV …”

Synthesis and Computational Analysis of New Antioxidant and Antimicrobial Angular Chromenopyrimidines

“…In addition, chromene scaffolds became privileged skeletons because of their wide medicinal activities . Because enhanced medicinal activity might be produced via combining two or more biologically active segments, pyrimidine and chromene units might be appropriate candidates to build an elegant hydrid model .…”