Synthesis and antiproliferative activity of some new fluorinated Schiff bases derived from 1,2,4-triazoles

Kumar, Basavapatna N. Prasanna; Mohana, K. N.; Mallesha, L.

doi:10.1016/j.jfluchem.2013.08.008

Cited by 41 publications

(9 citation statements)

References 21 publications

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“…The Schiff bases are also used as intermediates for the synthesis of important drugs, pesticides, and other natural products because of the conversion possibility of CN group to the desirable functional groups through reduction, addition, cyclization, and aziridination reactions 6–11 . Furthermore, anti‐bacterial, anti‐fungal, anti‐oxidant, anti‐tumor, anti‐viral, anti‐HIV, anti‐inflammatory, and anti‐proliferative properties of Schiff bases have been reported in the literature 12–25 . Besides the biological importance, the transition metal complexes, which can be obtained from σ‐donor and π‐acceptor Schiff bases as ligands, have wide catalytic applications in many reactions 26–30 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of new Schiff bases; Investigation of their in situ catalytic activity for Suzuki CC coupling reactions and antioxidant activities

Yılmaz

2021

J Chinese Chemical Soc

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New series of Schiff bases have been synthesized from the reaction between cyclohepta-2,4,6-trien-1-ylmethanamine and different aldehydes, and characterized via using 1 H NMR, 13 C NMR, FTIR spectroscopy, and GC-MS. After the successful synthesis, the in situ catalytic activity of all Schiff bases have been examined for the Suzuki C C cross-coupling reactions using phenylboronic acid, aryl bromides, and PdCl 2 as a catalyst. Before starting these investigations, reaction conditions were optimized using different bases and solvents. At the end of these reactions, the best efficiency was obtained in Et 3 N and EtOH. In addition to catalytic investigations, antioxidant activities of all synthesized Schiff bases were examined using DPPH and Iron (Fe 2+ ) chelation methods, and IC 50 values were calculated. While many molecules show various amounts of antioxidant activity, especially molecules 8e and 8g showed the best activity compared to butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA), which were used as positive controls, in DPPH and Iron chelating methods, respectively.

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Section: Introductionmentioning

confidence: 99%

Synthesis of new Schiff bases; Investigation of their in situ catalytic activity for Suzuki CC coupling reactions and antioxidant activities

Yılmaz

2021

J Chinese Chemical Soc

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“…Various derivatives of 1,2,4-triazolic nucleus, such as Schiff bases were investigated in the last decades, for the great variety of medical applications such as antimicrobial [1], hypoglycemic [2], anti-inflammatory [3], anticancer [4], fungicidal [5], anticonvulsant [6] and antiproliferative [7] activities. Schiff bases derived from 1,2,4-triazole are also studied for different technical purposes, such as corrosion inhibition for mild steel in acidic medium [8] or use as magnetic materials and photo-chemically driven molecular devices [9].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Degradation of Schiff Bases Containing Heterocyclic Pharmacophore

Ledeți

Alexa

Bercean

et al. 2015

IJMS

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“…Purines consist of a six-membered pyrimidine ring fused to a five-membered imidazole ring, which is the most broadly occurring nitrogen-containing heterocycle in nature. Imidazoles are significant on the grounds that their ChemistrySelect biological activity among their isomer, especially the imidazole had a broad range of biological potency including antimicrobial, [28][29][30] antituberculosis, [31] antioxidant, [32] antiinflammatory, [33,34] antiproliferative, [35,36] antitumor, [37,38] antiviral, [39] antipyretic, [40] anti-HIV-1, [41] antidepressant, [42] antihypertensive, [43] anticancer, [44] and antifungal activity. [45] These applications of imidazole led to the recent development of drugs and are regarded to be a potential candidate for pharmacological and therapeutic fields.…”

Section: Structure Features Of Imidazolementioning

confidence: 99%

An Insight into the Biological Properties of Imidazole‐Based Schiff Bases: A Review

2021

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Imidazole is an azole heterocycle containing two non-adjacent nitrogen atoms added greatly to natural products and synthetic compounds. The planar ring system associated with electronrich nitrogen donors are essential for the greater affinity of imidazole derivatives to bind with various bio receptors and enzymes via weak interactions. It improves the pharmacokinetic properties of the pilot molecules consequently utilized as a solution for aqueous solubility, bioavailability, and toxicity parameters since it is a polar compound. An organic molecule with imidazole derivatives has acquired a sustainable place in medical and clinical fields. The consolidation of the imidazole unit is a significant synthetic technique in drug development.The imidazole-based Schiff bases with enormous therapeutic properties has encouraged the scientists to focus on recently initiated novel chemotherapeutic agents such as anticancer, antimicrobial, antioxidant, antiviral, antileishmanial, etc. Imidazole drugs have expanded the degree of curing different dispositions in clinical medications. Herein, we have reported the structural feature of imidazole, design, synthesis of imidazole derivatives, and its significance. This review aims to describe the reported materials of imidazole-based Schiff bases and their derivatives which offer fruitful scope in the field of medicinal chemistry.

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Synthesis and antiproliferative activity of some new fluorinated Schiff bases derived from 1,2,4-triazoles

Cited by 41 publications

References 21 publications

Synthesis of new Schiff bases; Investigation of their in situ catalytic activity for Suzuki CC coupling reactions and antioxidant activities

Synthesis of new Schiff bases; Investigation of their in situ catalytic activity for Suzuki CC coupling reactions and antioxidant activities

Synthesis and Degradation of Schiff Bases Containing Heterocyclic Pharmacophore

An Insight into the Biological Properties of Imidazole‐Based Schiff Bases: A Review

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