An Insight into the Biological Properties of Imidazole‐Based Schiff Bases: A Review

Abstract

Imidazole is an azole heterocycle containing two non-adjacent nitrogen atoms added greatly to natural products and synthetic compounds. The planar ring system associated with electronrich nitrogen donors are essential for the greater affinity of imidazole derivatives to bind with various bio receptors and enzymes via weak interactions. It improves the pharmacokinetic properties of the pilot molecules consequently utilized as a solution for aqueous solubility, bioavailability, and toxicity parameters since it is a polar compound. An organic molecule with imidazole derivatives has acquired a sustainable place in medical and clinical fields. The consolidation of the imidazole unit is a significant synthetic technique in drug development.The imidazole-based Schiff bases with enormous therapeutic properties has encouraged the scientists to focus on recently initiated novel chemotherapeutic agents such as anticancer, antimicrobial, antioxidant, antiviral, antileishmanial, etc. Imidazole drugs have expanded the degree of curing different dispositions in clinical medications. Herein, we have reported the structural feature of imidazole, design, synthesis of imidazole derivatives, and its significance. This review aims to describe the reported materials of imidazole-based Schiff bases and their derivatives which offer fruitful scope in the field of medicinal chemistry.

Physical and electrochemical properties of new structurally flexible imidazolium phosphate ionic liquids

“…Imidazolium-based ILs have also received growing attentions for a variety of reasons including high thermal stability, relatively high ionic conductivity, broad electrochemical window, amphoteric features and plastic crystalline behavior . [26][27][28][29] As with all other ILs, the imidazolium cation can be coupled to a task-specific counter anion to boost the solubility, ionic conductivity and electrochemical properties as electrolytes in energy storage devices (ESDs). 30 Due to the growing interest in electrification, ESDs including batteries and supercapacitors (SCs) are the most widely utilized energy storage systems among.…”

“…Imidazolium-based ILs have also received growing attention for a variety of reasons including high thermal stability, relatively high ionic conductivity, a broad electrochemical window, amphoteric features and plastic crystalline behavior. 26–29…”

Synthesis, characterization and biological evaluation of Bis-benzimidazolium salts and their silver(I)-N-heterocyclic carbene complexes

“…NHCs are similar to phosphine ligands in how they coordinate with metals. Still, these carbenes are more attractive toward the metals than the phosphines, perhaps due to their more accessible synthetic methods [8,9].…”

Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors

“…Therefore, imidazole represents one of the most useful heterocyclic rings in medicinal chemistry. It is capable of serving as a ligand for a diverse array of receptors by mimicking the structure of peptides and binding reversibly to enzymes, providing incredible opportunities for drug discovery [ 30 , 31 , 32 , 33 ]. Additionally, different end-capping groups are introduced, creating two sets of symmetric compounds with the capping groups attached either in meta-meta or para-para substitution connected to the core.…”