Synthesis and antioxidant property of hydroxycinnamoyl maltodextrin derivatives

Abstract

Summary This study was focused on developing new hydroxycinnamoyl maltodextrin derivatives to evaluate their antioxidant activity and cytotoxicity. Vanillic acid, caffeic acid and ferulic acid were covalently attached to maltodextrin. The prepared derivatives were confirmed by ATR‐IR and 1H‐NMR. The thermal characteristics and viscosity were measured by thermogravimetric analysis and viscometer, respectively, and the studies revealed the grafted maltodextrins to be more thermal stable and viscous than the native maltodextrin. Moreover, the scavenging ability of most of the products was higher than 60% at 1 mg mL−1 against DPPH radical. The inhibitory effect of lipid peroxidation of caffeic acid and ferulic acid grafted maltodextrins attained 85% at 0.5 mg mL−1. It was also found that these compounds had no toxic effect (up to 100 μg mL−1) on the HEK 293 cells through the MTT test. These findings suggested that the prepared derivatives could potentially be used as a nontoxic antioxidant in food and drug industries.

Spray-Drying Microencapsulation of Bauhinia ungulata L. var. obtusifolia Aqueous Extract Containing Phenolic Compounds: A Comparative Study Using Different Wall Materials

“…All microencapsulated extracts had higher TAA values than the unencapsulated samples, indicating that the addition of encapsulating agents increased the ability of the extract to scavenge DPPH ∙ radicals. This result may be justified by the fact that the wall materials used in this study are described in the literature as antioxidants or secondary antioxidants, each capable of interacting with different types of radicals at different intensities and through different mechanisms [ 99 , 100 , 101 , 102 ]. In this sense, these agents, together with the compounds present in Bu-L, may have contributed to the scavenging of DPPH ∙ radicals.…”

The Effect of Ferulic Acid-Grafted Chitosan (FA-g-CS) on the Transmembrane Transport of Anthocyanins by sGLT1 and GLUT2

“…Few studies have demonstrated the operation and mode of action of microcapsule components (the wall materials) and carriers. In our previous studies, the bioavailability of ANCs was noticeably improved by grafting FA onto polysaccharides for preparing ANC microcapsules [ 18 , 19 ]. In addition, epigallocatechin gallate nanoencapsulated in ferulic acid-grafted chitosan (FA-g-CS) was confirmed to show dramatically increased stability and antioxidant activity [ 20 ].…”

Anthocyanin Encapsulated by Ferulic Acid-Grafted-Maltodextrin (FA-g-MD) Microcapsules Potentially Improved its Free Radical Scavenging Capabilities Against H2O2-Induced Oxidative Stress

“…For example, a series of phenolic acids were grafted onto chitosan, starch and cellulose, and their excellent antioxidant properties were correspondingly validated [16,17,18]. In our former study, we developed several new hydroxycinnamoyl maltodextrin derivatives and their antioxidant activity and cytotoxicity were also evaluated [19]. Among them, maltodextrin-grafted ferulic acid (FA-g-MD) showed the best antioxidant activity.…”

“…Among them, maltodextrin-grafted ferulic acid (FA-g-MD) showed the best antioxidant activity. Additionally, we found that anthocyanins encapsulated in maltodextrin-grafted-cinnamic acid can significantly enhance the stability of anthocyanins [19]. Bearing these in mind, FA-g-MD can be used as a potential wall matrix to improve stability of anthocyanins.…”