Synthesis and Antioxidant Activity of New Pyridines Containing Gallate Moieties

Abstract

Pyridines containing the galloyl moiety have been prepared utilizing 4-acetyl pyrogallol. In addition, fused pyridines were synthesized from the obtained pyridines via further chemical transformations. The results indicated that compound 4a showed stronger DPPH scavenging activity than the other compounds, and the scavenging effect decreased in the following order 4a > t-BHQ > 2a > 2b > 3a > 3b > 4b. Accordingly, other antioxidant assays were conducted for 4a. The results suggested that compound 4a could be a good antioxidant candidate. The absence of mortality of rats receiving 5000 mg/kg body weight of 4a as single oral dose may indicate that it could be a safe antioxidant and may be used for further studies.

Protective Effect of a Synthetic Antioxidant “Acetyl Gallate Derivative” Against Dimethoate Induced DNA Damage and Oxidant/Antioxidant Status in Male Rats

“…The antioxidant compound used in the experiment was prepared in our laboratory according to El-Ebiary et al [18].…”

“…Vitamin C (VC), as a water soluble antioxidant is reported to neutralize reactive oxygen species (ROS) and reduce oxidative DNA damage and hence genetic mutations [16,17]. In our laboratory, newly synthesized compounds utilizing acetyl gallate derivatives (SAC) have been tested in vitro as antioxidants [18]. The 2-Cyano-N-[1-(2', 3', 4'-trimethoxyphenyl)ethylidene]acetohydrazide ( Figure 1) showed an interesting antioxidant activity and absence of mortality of rats received 5000 mg kg -1 b.wt.…”

Development of new indole-derived neuroprotective agents

“…These findings could be attributed to the indole moiety which has remarkable antioxidant properties. In addition, the newly synthesized compounds 9b, 17, 12c, and 14a containing pyridine, 31 tetrazole, 30 pyrimidine, 32 and pyrazole 33 rings, respectively, possess antioxidant and free radical scavenging properties. These compounds could suppress oxidative stress with consequent inhibition of lipid peroxidation product (MDA), enhance antioxidant enzyme activities (SOD, GPx) and induce GSH synthesis.…”

Synthesis and antioxidant assay of new nicotinonitrile analogues clubbed thiazole, pyrazole and/or pyridine ring systems

“…Nicotinonitrile nucleosides have attracted attention because of their motivating pharmacological activities as antiviral, antitumor, antibacterial, anticancer, antioxidants, and other biological activity . Moreover, several thiazole, pyrazole, and pyridine moieties were reported to possess antioxidant activity. Thus, the convergent synthetic strategy of the titled heterocyclic hybrids was carried out with three objectives.…”