Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles

Boric acid-catalyzed multi-component reaction for efficient synthesis of 4H-isoxazol-5-ones in aqueous medium

“…One of the best methods for achieving these systems is the use of MCRs. This five-membered heterocyclic unit represents a class of heterocyclic compounds with biological activities and medicinally useful agents such as anticonvulsant [4], antifungal [5], analgesic [6], antitumor [7], antioxidant [8], antimicrobial [9], H. Kiyani (&) Á F. Ghorbani School of Chemistry, Damghan University, 36715-364 Damghan, Iran e-mail: hkiyani@du.ac.ir COX-2 inhibitory [10], anti-inflammatory [11], antiviral [12], and antimycobacterial [13], as well as being used for the treatment of leishmaniasis [14] and of patients with active arthritis [15]. Furthermore, the isoxzolon core can also be used as the basis for the design and construction of merocyanine dyes, which are used in optical recording and nonlinear optical research [16].…”

Synthesis and evaluation of biological activities of new sulfonamide and carbamate derivatives of 1H-pyrrolo[2,3-b]pyridine (7-azaindole)

“…The experiment was repeated in triplicate, and the results were averaged and are presented in Table 2. The DPPH assay [26] was considered to be the preliminary screening of the compounds which provided information about the reactivity of the tested compounds with a stable free radical. The degree of decolorizing indicates the potentiality of the anti-oxidant drug.…”

Antioxidant and antimicrobial studies on fused-ring pyrazolones and isoxazolones

“…Pyrazolone and oxazolones possess similar general properties in a wide spectrum of biological activities such as anti-tubercular, antiviral, anti-hypertensive, antioxidant, anti-depressant, neuroprotective, anti-diabetic, antibacterial, anti-fungal, anti-inflammatory and anticancer. [1][2][3][4][5][6] Antipyrine (2,3-dimethyl-1-phenyl-3-pyrazolin-5-one) is a pyrazolone used as an anti-fever and in management of pain and inflammation, 7 while linezolid, Zyvox™ is an oxazolidinone used against infections caused by multi-drug resistant Gram-positive bacteria. 8 Several synthetic methods have been employed in literature for the synthesis of pyrazolone and oxazolones.…”