Synthesis and Antioxidant Activity of Styrylsulfonylmethyl 1,3,4-Oxadiazoles, Pyrazolyl/Isoxazolyl-1,3,4-oxadiazoles

Abstract

A new class of mono and bis heterocycles-styrylsulfonylmethyl 1,3,4-oxadiazoles, pyrazolyl/isoxazolyl-1,3,4-oxadiazoles were prepared and studied their antioxidant activity. The compound methyl substituted 2-(p-methylphenylamino-sulfonylmethyl)-5-[Z-(p-methylstyrylsulfonylmethyl)]-1,3,4-oxadiazole displayed slightly higher antioxidant activity than the standard ascorbic acid.

Pharmacokinetic evaluation, molecular docking and in vitro biological evaluation of 1, 3, 4-oxadiazole derivatives as potent antioxidants and STAT3 inhibitors

“…The synthesized compounds (Scheme 1) ( 4a–5f ) reported by us previously [1] were tested for their antioxidant potential using the DPPH [37], NO [38], H 2 O 2 [2], O 2 - [39], total reducing capacity [2] and total antioxidant assays [40]. The results for the in-vitro antioxidant assays for the synthesized compounds and the standard antioxidant were compared.

Scheme 1Schematic representation for synthesis protocol for compounds (4a–5f) .

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Current progress on antioxidants incorporating the pyrazole core

“…Antioxidant activity of compounds 93-104, bis-heterocycles 105-108, bispyrazoles 109 and bis(pyrazolines and pyrazoles) 111 and 112 (Fig. 13) was evaluated by DPPH, nitric oxide and hydrogen peroxide methods [54,55,56,57]. Compounds 95b, 97b, 99b, 101b…”