Synthesis and antioxidant activities of some new triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings

Abstract

Various triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings (3-6) were synthesized and screened for their antioxidant activities. The structures of the synthesized compounds (2-6) were judged by 1 H NMR, 13 C NMR, elemental analysis, and LC-MS spectral data. Antioxidant activities of the synthesized compounds (2-6) were determined with CUPric Reducing Antioxidant Capacity (CUPRAC), ABTS (2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)/persulfate, and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays. Most of the compounds showed a significant antioxidant activity and especially, compound 5c showed very good SC 50 value for DPPH method and compound 5h exhibited very high scavenging activity to ABTS method.

Investigation of a wild pear species (Pyrus elaeagnifoliasubsp.ElaeagnifoliaPallas) from Antalya, Turkey: polyphenol oxidase properties and anti-xanthine oxidase, anti-urease, and antioxidant activity

“…reducing antioxidant capacity (CUPRAC) of AePep was determined according to the method in the literature[25,26]. Trolox® (Sigma Chemical Co, USA) was also tested under the same conditions as a standard antioxidant compound.…”

“…Radical scavenging activity was measured by using butylated hydroxy toluene (BHT) as standard and all values are expressed as SC 50 , the concentration of the samples that caused 50% scavenging of DPPH radical. The ability of AePep to scavenge ABTS •+ (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)) radical was determined according to the literature[26,27]. All determinations were carried out three times, using BHT as standard.…”

Synthesis and In Vitro Urease Inhibition of Some Novel Benzimidazole‐based Hydrazones

“…Benzimidazoles are clearly known as significant chemical species with a wide range of biological activities including antioxidant , anticancer , antimicrobial , enzyme inhibition , and great potential. Benzimidazole and its derivatives have an important role in the field of medicine.…”

Synthesis of some novel pyrazolopyrimidotriazepine, pyrazolotriazolopyrimidine, and pyrazolopyrimidotetrazine derivatives

“…Pyrazolopyrimidines occupy an important place in medical chemistry due to their biological activities [1][2][3][4][5][6][7][8][9][10] and their structural resemblance to purines. [14][15][16][17] On the other hand, 1,2,4-triazoles play very important role in the medicinal chemistry due to different biological activities such as antioxidant, [18] analgesic [19] antimalarial, [20] anti-carbonic anhydrase, [21] antiviral, [22] antibacterial, [23] fungicidal, [24] anti-xanthine oxidase, and anti-urease. [11,12] In addition, pyrazolopyrimidines possess antiviral, [13] anti-inflammatory, analgesic, gastroprotective, and ulcerogenic activities.…”