Synthesis and Antimicrobial Evaluation of New 5-Amino-2,3-dihydrophthalazine-1,4-dione Derivatives

Abstract

5-Amino-2,3-dihydrophthalazine-1,4-dione (Luminol 1) reacted with some organophosphorus reagents such as phosphonium ylides, trialkyl phosphites, and tris(dialkylamino)phosphines to afford the corresponding olefinic products 5a-e, alkoxy-, and dialkylamino derivatives of Luminol 6a-e. 4-Thioxo-3,4-dihydrophthalazin-1(2H)-one derivative 7 was synthesized from the reaction of Luminol (1) with thiating Lawesson and Japanese reagents. Structures of the synthesized compounds were clarified based on their elemental and spectroscopic analyses. The synthesized compounds were evaluated for their antimicrobial activity against some bacterial and fungal strains.

Synthesis, characterization, docking studies and anti-inflammatory activity of new safe NSAIDs agent based on Ibuprofen phenylalanine derivatives

“…In continuation of synthesis of effective candidates in our laboratory as antimicrobial, antiviral, and anticancer agents [19][20][21][22][23]; we aim to conjugate Ibuprofen with phenyl alanine to be an effective agents as antiinflammatory and analgesic. Our strategy based on preparation of ibuprofen derivatives 1-17 starting from acid chloride 2 that may be expected to have biological activities (Scheme 1).…”

Synthesis, characterization and investigation of antibacterial activity for some new functionalized luminol derivatives

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