Synthesis and Antimicrobial Evaluation of Some New 1,2-Bis-(2-(<i>N</i>-arylimino)-1,3-thiazolidin-3-yl)ethane Derivatives

Novel Bis-Thiazole Derivatives: Synthesis and Potential Cytotoxic Activity Through Apoptosis With Molecular Docking Approaches

“…Our research interest is focused on the synthesis and biological evaluation of thiazole-based heterocycles (Abdel-Gawad et al, 2010;Dawood and EI-Deftar, 2010;Hegazi et al, 2010;Dawood et al, 2011;Dawood et al, 2013;Dawood and Abu-Deif, 2014;Dawood, 2019;Mahmoud et al, 2020). Therefore, keeping the above facts in mind and inspired by the reported extraordinary bioactivity behaviors of thiazole and 4thiazolidinone derivatives, the objective of the current study is to design and synthesize new bis-thiazole structures for examining their potency against several of human cancer cell lines as well as investigating their effects as an inducer of apoptosis on the tested cancer cells.…”

Bis‐thiourea Derivatives and Their Utility in Synthesis of Mono‐heterocyclic, Bis‐heterocyclic, and Fused Heterocyclic Systems

“…When the N , N′ ‐diphenyl‐ethylene‐bis‐thiourea 14 was allowed to react with α‐bromoketone 114 (in 1:2 molar ratio) in EtOH/Et 3 N at reflux, it yielded the corresponding 1,2‐bis‐(2‐phenylimino‐1,3‐thiazolidin‐3‐yl)ethane derivative 127 in high yields. Treatment of the bis‐thiourea 14 with 2 equiv of α‐chloro dicarbonyl compound 128 afforded the symmetrical 1,2‐bis‐[thiazolidin‐3‐yl]ethane derivative 129 (Scheme ) .…”

“…Treatment of the ethylene ‐ bis‐thiourea 14 with 2 equiv of hydrazonoyl halide 135 in EtOH/Et 3 N at reflux furnished the bis‐1,3‐thiazolidine derivative 136 in good yields (Scheme ) .…”

“…Some bis‐thiourea derivatives were also applied as anion selective fluorescent chemosensors , and some had enantiomeric recognition ability . As part of our research work towards utilization of thiourea derivatives in synthesis of various heterocycles with broad biological activities , in this review article, the synthetic routes towards bis‐thiourea as well as their applications in synthesis of various classes of heterocyclic systems are extensively surveyed.…”

Design and synthesis of new bis(1,2,4-triazolo[3,4-b][1,3,4]thiadiazines) and bis((quinoxalin-2-yl)phenoxy)alkanes as anti-breast cancer agents through dual PARP-1 and EGFR targets inhibition

“…During our research program aiming at synthesis of triazolebased fused heterocycles, bis(carboxamides) and bis(heterocycles) as twin drugs of signicant biological applications, [45][46][47][48][49][50][51][52][53][54][55] the reported anticancer activities of compounds employing either triazolothiadiazine or carboxamide pharmacophores inspired us to construct a series of modied novel bistriazolothiadiazine hybrids (Fig. 3) having variable bis(carboxamide) spacers, starting from bis(2-chloroacetamide) derivatives, to investigate their potency as anticancer agents against a panel of cancer cell lines and to investigate the effective molecular target and the apoptotic cell death.…”