Synthesis and Antimicrobial Assessment of Some New 2-(Thiazol-5-yl)-1,3,4-oxadiazoles

Abstract

Considering the promising antimicrobial activity of compounds bearing the thiazole or the oxadiazole rings in their structures, we set out to obtain new antimicrobial molecules bearing the 2-(thiazol-5-yl)-1,3,4-oxadiazole schaffold. The structures of the 8 new compounds obtained was confirmed by physicochemical characterization including: 1H-NMR, MS and elemental analysis. Antimicrobial activity was investigated against 5 Gram-positive bacterial strains, 2 Gram-negative bacterial strains and 2 fungal strains. The newly synthesized compounds showed modest antimicrobial activity.

Antimicrobial Activity and Sar of 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives

“…The results revealed that compounds (17)(18) exhibited better antibacterial activity than standard drug Ampicillin except against E. coli (Table 9). In case of antifungal activity compounds (17)(18) showed reduced activity as compared to standard drug Miconazole ( 12) [55]. 13).…”

“…Compound 55 found to be most active (ZOI = 69.5-80.5 mm) against most of the tested fungal strains among synthesized derivatives (Table24). Overall active compounds(54)(55)(56) showed excellent activity as compared to standard drugs Clotrimazole and Ciprofloxacin (Table23, 24)[66]. S. aureus, E. coli and P. aeruginosa (MIC range = 12.5-25 µg/mL) except 57 against E. coli (MIC = 50 µg/mL)…”