Synthesis and antimicrobial activity of new bromine-rich pyrrole derivatives related to monodeoxypyoluteorin

Synthesis and anti‐staphylococcal activity of new halogenated pyrroles related to Pyrrolomycins F

“…The 3',5'-dichloro-2-(2'-methoxybenzoyl)pyrrole 6, so obtained, was purified by column chromatography. The subsequent halogenation of compound 6, was carried out using N-bromosuccinimide (NBS) or N-chlorosuccinimide (NCS) in acetonitrile as previously described [12][13]; so the bromination of 6 using three molar equivalents of NBS afforded the 3,4,5-tribromoderivative 7. Demethylation of 7 with aluminium chloride in anhydrous dichloromethane at room temperature, afforded to the 2'-hydroxy derivative 2 in excellent yield (Scheme 1).…”

Crystal structure of methyl-2-methyl-4-(2-oxo-2-phenylethyl)-5-phenyl-1H-pyrrole-3-carboxylate, C21H19NO3

“…The pyrrole [4][5][6][7] ring is one of the most common skeletal features found in heterocycles and natural products [8][9][10]. Generally, pyrroles possess a broad spectrum of biological activities such as antimicrobial [11], telomerase inhibitory [12], antifungal [13], cardiotonic [14], pheromonal [15], and phytotoxic e ects [16]. The classical approaches for synthesizing pyrroles are Knorr [17,18], Hantzsch [19][20][21], and Paal-Knorr …”

Novel Antiviral Compounds against Gastroenteric Viral Infections

“…Several synthetic chemical compounds showed antiviral activity. It is noted that the pyrrole nucleus plays a vital role in many biological activities . Also, pyrrolo[2,3‐ d ]pyrimidines as 7‐deaza analogs of biogenic purines are of considerable interest both from chemical and biological points of view.…”