Novel Antiviral Compounds against Gastroenteric Viral Infections

Abstract

Viral gastroenteritis is a serious viral infection which affects a large number of individuals around the world, most of them being children. The infection may occur due to different viruses, for example, coxsackievirus, adenovirus, and rotavirus. There is no available cure for such infections, and the treatment mainly depends on hospitalization and administration of nutritional supports. A new antiviral agent against gastroenteritis viral infection will be a breakthrough in healthcare. Pyrrole and pyrrolopyrimidine derivatives are well known for their biological activity as antibacterial, antifungal, and anticancer agents. These compounds also proved to possess antiviral activity. Here, we synthesized novel pyrrole and pyrrolopyrimidine compounds and examined their antiviral activity. We synthesized several new pyrrole, pyrrolo[2,3-d]pyrimidine, and pyrrolo[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives. The characterization of all synthesized compounds was based on microanalysis and spectral data. Moreover, we determined the non-toxic doses of these compounds on BGM, Hep-2, and MA-104 cells. We tested all the synthesized compounds for their antiviral activities against coxsackievirus B4, adenovirus type 7, and rotavirus Wa strain. Several compounds exhibited significant activities as antiviral agents.

USC-087 protects Syrian hamsters against lethal challenge with human species C adenoviruses

“…Very recently, a number of other compounds and agents have been shown to have anti-HAdV activity in cell culture. These include cardiotonic steroids (Grosso et al, 2017), 3-hydroxy-quinazoline-2,4(1 H ,3 H )-diones (Kang et al, 2016), phenols in black tea extract (Karimi et al, 2016), dioscin, a compound extracted from air potato (Liu et al, 2013), 6-azacytidine (Alexeeva et al, 2015), and pyrrole and pyrrolopyrimidine compounds (Hamdy and El-Senousy, 2013; Mohamed et al, 2015).…”

Exploration of the Chemistry and Biological Properties of Pyrimidine as a Privilege Pharmacophore in Therapeutics

“…1,2,3,4tetra hydropyrimidine analogue was found to be potent against various human cancer cell lines (Bari et al, 2015). Triazolo-pyrimidinone (Mohamed et al, 2015b) and pyrazolo-pyrimidine (Pogorelcnik et al, 2015) with the structures shown in Fig. 40, revealed promising anticancer activities compared to the activity of the commonly used anticancer drug, doxorubicin in both MCF-7 and A549 cell lines.…”

Microwave‐assisted Synthesis of 5,6,7‐Trisubstituted Pyrrolo[2,3‐d]Pyrimidines via Palladium‐catalyzed Heteroannulation with Internal Alkynes

“…Many of the synthetic methods used to produce pyrrolo[2,3‐ d ]pyrimidines predominantly employ a dual‐heterocycle formation approach (Scheme ) . In one such approach, a pyrimidine ring is added to an aptly substituted pyrrole via the consecutive formation of two amide bonds using urea derivatives, esters, isocyanates, and formamides.…”