“…The structural similarity of 1,4-benzothiazines I (Figure ) to pharmacologically important 10 H -phenothiazines II has triggered considerable interest in synthetic and biological studies of this class of compounds. − 1,4-Benzothiazines I and their analogues are well documented to exhibit pharmacologically relevant activities, including sedative, anthelmintic, antiulcer, anticancer, antibacterial, and antifungal effects. − They also inhibit acetylcholinesterase (AchE), which is responsible for several neurological disorders, such as Parkinson’s and Alzheimer’s diseases . In addition, numerous benzothiazines are in clinical development as antipsychotics, analgesics, diuretics, antitussives, and antihistamines. , The corresponding S-oxidized 4 H -benzo[ b ][1,4]thiazine 1,1-dioxide analogues III − were first described in 1968. Since then, they have assumed a prominent role in organic synthesis, medicinal chemistry, and the chemical industry. , Several analogues of III have been isolated from a bryozoan .…”