Synthesis and antimicrobial activity of new substituted anilinobenzimidazoles

Abstract

A series of benzimidazole derivatives carrying different heterocycles such as 1,2,3-thiadiazole, 1,3,4-thiadiazole, thiazolidine, 2,3-dihydro-thiazole, 1,3,4-oxadiazole, semicarbazone and substituted thiosemi-carbazones were synthesized. Also a series of 1-methylbenzimidazole carrying hydroxy ethyl-amide, substituted sulfonyl hydrazide and benzoyl hydrazide from aminobenzoyl group at position 2 of 1-methylbenzimidazole were synthesized. The antimicrobial evaluation of some of the new compounds was carried out.

5-(4-pyridinyl)-1,3,4-oxadiazole-2-thiol on gold: SAM Formation and electroactivity

“…(3) For the calculation of the parameter, a diffusion coefficient of 1.0 10 -6 cm 2 s -1 was used. 35 The k 0 value calculated for the Cyt c on Hpyt SAM was 2.29 10 -3 cm s -1 and resulted to be lower than those calculated for the SAMs formed with pyS (6.0 10 -3 cm s -1 ) and [Ru(CN) 5 (pyS)] 3-complex (8.0 10 -3 cm s -1 ) on gold. 24,36 Taking into account the similarity between the charge density on the terminal group of these modifiers and on the nitrogen terminal atom of the Hpyt SAM, the results can be explained by differences in the configuration of the adsorbates on surface.…”

“…24,36 Taking into account the similarity between the charge density on the terminal group of these modifiers and on the nitrogen terminal atom of the Hpyt SAM, the results can be explained by differences in the configuration of the adsorbates on surface. Previously reported results 19,24 indicate a trans conformation of pyS and [Ru(CN) 5 (pyS)] 3-adsorbates on gold surface. The terminal functional group in these modifiers is directly pointing to the Cyt c molecules in the electrolytic phase.…”

“…5,6 Despite these aspects, there are no data in the literature concerning the use of this type of compound as electrochemical biological sensor. Within this compound class, 5-(4-pyridinyl)-1,3,4-oxadiazole-2-thiol (Hpyt) species is particularly interesting because of the possibility to study the effect of SAM protonation equilibrium, which is one of the processes that influence h ET .…”

Zinc metalloenzymes as new targets against the bacterial pathogen Brucella

“…A second series of inhibitors was then designed to optimize the inhibition capacity by intercalation of a sulfonyl hydrazide moiety. The presence of such a moiety in compounds of biological interest was previously proved successful to the targeting of metalloenzymes [51,52]. The straightforward synthesis occurred from L-histidine in 7 steps [53].…”

Brucella suishistidinol dehydrogenase: Synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide

“…All the synthesized compounds 3 listed in Figure 2 were fully characterized by 1 H-NMR, 13 C-NMR and mass spectral data.…”