Synthesis and Antimicrobial Activities of Iminothioether Linkers on Cyclopenta[a]phenanthrene Derivatives

Abstract

The reaction of methylbenzo[h] [1,6]naphthyridine (1) with thiourea yield 4-chloro-12-methyl-16,17-dihydro-15-thia-6,11-diazacyclopenta[a]phenanthrene-7-thiol (2). The chemistry of compound 2 is explored to obtained iminothioether derivatives (3a-h) in good yields. The structures of newly synthesized compounds were confirmed by spectral data and elemental analysis. The antimicrobial activity of newly synthesized compounds were studied against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeroginosa, Proteus valgaris, Bacillus cereus, Streptococcus sp. and Bacillus megaterium by the agar well diffusion method. Compounds 3d, 3f and 3h showed moderate antimicrobial activity.