Synthesis and antimicrobial activities of new quats

Skrzypczak, Andrzej; Brycki, Bogumił; Mirska, Ilona; Pernak, Juliusz

doi:10.1016/s0223-5234(97)83292-8

Cited by 35 publications

(23 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cybulski et al [15] have also found that the phytotoxicity of ionic liquids is dependent on the type of cation or anion, as well as on the length of the alkyl chain. Some authors report that the highest antimicrobial activity is exhibited by substances whose substituent contains from 10 to 16 carbon atoms [66,67]. The authors' own studies have not confirmed this observation, because the iodide containing the hexadecyl substituent has turned out to be less toxic to plants than the iodide with the methyl group.…”

Section: Resultsmentioning

confidence: 94%

Comparison of Phytotoxicity of Selected Phosphonium Ionic Liquid

Biczak

Bałczewski

Pawłowska

et al. 2014

Ecological Chemistry and Engineering S

View full text Add to dashboard Cite

Ionic liquids have attracted considerable interest in various areas as new, non-volatile and nonflammable organic solvents, catalysts, reaction additives, ligands, drugs and other dedicated materials etc. Their general use, sometimes in bulky quantities, requires determination of their potential ecotoxicity on selected organisms. In the present work, influence of triphenylmethylphosphonium iodide (1) and triphenylhexadecylphosphonium iodide (2), introduced to soil, on germination and early stages of growth and development of superior plants was investigated using the plant growth test based on the OECD/OCDE 208/2006. In this test, the seeds of selected species, i.e. land superior plants -spring barley (Hordeum vulgare) and common radish (Raphanus sativus L. subvar. radicula Pers.) were planted in pots containing soil to which a test chemical compound had been added and in pots with control soil. To evaluate the phytotoxicity of ionic liquids 1 and 2 germination and weight (dry and fresh) of control plant seedlings were determined and compared with the germination and weight (dry and fresh) of the seedlings of plants grown in the soil watered with appropriate amounts of the test chemicals. The visual assessment of any types of damage to the test species, such as growth inhibition, chlorosis and necrosis, was also carried out and documented by digital photographs. Based on the obtained results, magnitudes of the LOEC -the lowest concentration causing observable effects in the form of reduction in growth and germination compared with the control and the NOEC -the highest concentration not causing observable, toxic effects -were also determined.

show abstract

Section: Resultsmentioning

confidence: 94%

Comparison of Phytotoxicity of Selected Phosphonium Ionic Liquid

Biczak

Bałczewski

Pawłowska

et al. 2014

Ecological Chemistry and Engineering S

View full text Add to dashboard Cite

show abstract

“…Thus, it is hard to compare the obtained results of the analysis with those presented in the earlier publications [28,29]. The strong decision rules of the classification I (Pseudomonas aeruginosa) present distinct information about active compounds with N-decyl substituent as long as the free energy of adsorption of molecule, the parameter a of the Szyszkowski equation and the surface tension at critical micelle concentration are equal to particular values.…”

Section: Resultsmentioning

confidence: 95%

“…Previous research works performed the SAR analysis of attributes describing ammonium chlorides structure in view of their antimicrobial activity on Staphylococcus aureus strain [28,29]. Thus, it is hard to compare the obtained results of the analysis with those presented in the earlier publications [28,29].…”

Section: Resultsmentioning

confidence: 99%

“…The strong decision rules of the classification I (Pseudomonas aeruginosa) present distinct information about active compounds with N-decyl substituent as long as the free energy of adsorption of molecule, the parameter a of the Szyszkowski equation and the surface tension at critical micelle concentration are equal to particular values. Whereas the SAR analysis focused on the Stapylococcus aureus strain indicated that chlorides with N-dodecyl substituent belong to the group of active ammonium compounds [28].…”

Section: Resultsmentioning

confidence: 99%

“…The synthesis and antibacterial activity of the analyzed chlorides were described by the authors earlier [28,29].…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Analysis of Relationships Between Structure, Surface Properties, and Antimicrobial Activity of Quaternary Ammonium Chlorides

et al. 2009

View full text Add to dashboard Cite

The research concerns analysis of cause-effect relationships occurring between condition attributes describing structure and surface-active properties and decision attributes (antimicrobial activity) of alkyl(alkylthiomethyl)dimethylammonium chlorides and alkyl(alkoxymethyl)dimethylammonium chlorides. 72 ammonium chlorides were described by 7 condition attributes concerning structure and 7 condition attributes concerning surface-active properties. Antimicrobial activity was expressed by minimal inhibitory concentration (MIC) against strains of Pseudomonas aeruginosa ATCC 15442 (classification I) and Candida albicans ATCC 10231 (classification II). The ROSE 2 (Rough Sets Data Explorer) and LEM 2 (Minimal Set Covering Algorithm) software were used to perform the analysis. Attributes with continuous values were discretized. 45 decision rules were generated in the classification I, and 38 rules in the classification II. Those described the most important dependencies between structure, surface-active properties of analyzed chlorides and their antimicrobial activity. Strong decision rules supported by large number of objects provide guidelines which may facilitate synthesis of new compounds with preferable antimicrobial properties.

show abstract