Synthesis and antiinflammatory activity of 5-(1,2-dihydropyridyl)-tetrazol-2-acetic acids, esters and amides

Knaus, EE; Kumar, Piyush

doi:10.1016/0223-5234(93)90040-l

Cited by 11 publications

(2 citation statements)

References 8 publications

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“…They have found use in pharmaceuticals as lipophilic spacers and carboxylic acid surrogates, which improves oral absorption [7]. Their derivatives were reported to possess broad spectrum of biological activity in both medicinal and pharmaceutical areas such as antinociceptive [8], antibacterial [9], antifungal [10], anti-HIV, anticancer, immunosuppressive [11], anti-inflammatory [12] and antiulcer [13], antiproliferative [14], antiallergic [15], and analgesic [16] activities.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and In Vitro Antimicrobial Evaluation of Fused Pyrano[3,2-e]tetrazolo[1,5-c]pyrimidines and Diazepines

Kanakaraju

Kumar

Prasanna

et al. 2013

ISRN Organic Chemistry

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A series of novel pyranochromene-containing tetrazoles fused with pyrimidinethiones, pyrimidines, and diazepines 3a–f, 4a–f, and 5a–f were synthesized by condensation of the corresponding tetrazoles 2a–f with carbon disulfide, benzaldehyde, and 4-methoxy phenacyl bromide, respectively. The compound 2a–f was obtained by reaction of pyrano[3,2-c]chromenes 1a–f with sodium azide. The structures of the newly synthesized compounds 2a–f to 5a–f were established on the basis of their elemental analyses, IR, 1H NMR, 13C NMR, and mass spectral data. All of the title compounds were subjected to in vitro antibacterial testing against four pathogenic strains and antifungal screening against two fungi. Preliminary results indicate that some of them exhibited promising activities and that they deserve more consideration as potential antimicrobials.

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Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and In Vitro Antimicrobial Evaluation of Fused Pyrano[3,2-e]tetrazolo[1,5-c]pyrimidines and Diazepines

Kanakaraju

Kumar

Prasanna

et al. 2013

ISRN Organic Chemistry

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“…(Figure 15) possesses anti-in°ammatory activity better than ibuprofen in carrageenan induced rat paw edema assay and has been synthesized and reported in the lit. [43].…”

Section: Development Of Safer Non Speci¯c (Cox-1 and Cox-2 Inhibitors) mentioning

confidence: 99%

Heterocyclic inflammation inhibitors

et al. 2004

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Non steroidal anti-in®ammatory drugs are the most widely used medicines for relief of pain. These drugs have some side e¬ects, particularly toxicity in the gastrointestinal tract and kidneys. Various approaches have been used for obtaining safer anti-in®ammatory drugs. In this review we have summarized the recent developments in the following areas; (i) Mode of action of NSAIDs, (ii) Role of COX-1 & COX-2 in in®ammation, (iii) Di¬erent approaches used to improve gastric tolerance i.e chemical manipulation, formulation & co-administration, development of non speci c (COX

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ChemInform Abstract: Synthesis and Antiinflammatory Activity of 5‐(1,2‐Dihydropyridyl)‐ tetrazol‐2‐acetic Acids, Esters and Amides.

Knaus

Kumar

1994

ChemInform

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Synthesis and antiinflammatory activity of 5-(1,2-dihydropyridyl)-tetrazol-2-acetic acids, esters and amides

Cited by 11 publications

References 8 publications

Design, Synthesis, and In Vitro Antimicrobial Evaluation of Fused Pyrano[3,2-e]tetrazolo[1,5-c]pyrimidines and Diazepines

Design, Synthesis, and In Vitro Antimicrobial Evaluation of Fused Pyrano[3,2-e]tetrazolo[1,5-c]pyrimidines and Diazepines

Heterocyclic inflammation inhibitors

ChemInform Abstract: Synthesis and Antiinflammatory Activity of 5‐(1,2‐Dihydropyridyl)‐ tetrazol‐2‐acetic Acids, Esters and Amides.

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