Design, Synthesis, and In Vitro Antimicrobial Evaluation of Fused Pyrano[3,2-e]tetrazolo[1,5-c]pyrimidines and Diazepines

Abstract

A series of novel pyranochromene-containing tetrazoles fused with pyrimidinethiones, pyrimidines, and diazepines 3a–f, 4a–f, and 5a–f were synthesized by condensation of the corresponding tetrazoles 2a–f with carbon disulfide, benzaldehyde, and 4-methoxy phenacyl bromide, respectively. The compound 2a–f was obtained by reaction of pyrano[3,2-c]chromenes 1a–f with sodium azide. The structures of the newly synthesized compounds 2a–f to 5a–f were established on the basis of their elemental analyses, IR, 1H NMR, 13C NMR, and mass spectral data. All of the title compounds were subjected to in vitro antibacterial testing against four pathogenic strains and antifungal screening against two fungi. Preliminary results indicate that some of them exhibited promising activities and that they deserve more consideration as potential antimicrobials.

Tetrazolium Compounds: Synthesis and Applications in Medicine

“…Fluconazole was used as a reference antifungal agent. The study showed that compounds 34 , 35 , 36 and 37 showed significant antibacterial and antifungal activities compared with other tested samples [ 45 ].…”

Synthesis of 3,4-dihydropyrano[c]chromene derivatives using porous copper oxide as nanocatalyst and their electrochemical study

“…Dihydropyrano [c]chromenes and their analogs are important compounds because they have diversity in several biological features 3 , which are antihypertensive, anticoagulation 4 , anti-cancer 5 , and anti-anaphylactic action 6 .…”

Synthesis and Characterization of New Polymers Bearing Tetrazole and Triazole Moieties with Studying their Corrosion Protection of Stainless Steel Surface in Hydrochloric Acid

“…The development of tetrazole chemistry has been largely associated with the widespread use of these compounds in medicine, biochemistry, agriculture, material sciences, etc. [11][12][13][14][15][16]. Also, tetrazole possesses a unique combination of properties of substantial thermal stability along with high positive enthalpy rates of formation and the highest nitrogen content among organic compounds with relatively high stability [17].…”