Synthesis and antihistaminic activity of some thiazolidin-4-ones

Abstract

A new series of 2-(4- and 3-substituted phenyl)-3-[3-(N,N-dimethylamino) propyl]-1,3-thiazolidin-4-ones were synthesized, characterized, and evaluated for their ability to inhibit the contractions induced by histamine on guinea pig ileum. The measurement of pA2 values suggested that the reported compounds showed H1-antagonism. The more active compounds 5, 9, and 13 exhibited activity close to that of mepyramine.

One-Pot Synthesis of 5-Arylidene-2-Imino-4-Thiazolidinones under Microwave Irradiation

“…4-Thiazolidinone derivatives constitute an important class of heterocyclic compounds for their potential pharmaceutical applications [1][2][3][4][5][6][7][8]. Consequently, a large number of synthetic protocols leading to these compounds have been reported in the literature [9].…”

Microwave-assisted Synthesis of Hybrid Heterocycles as Potential Anticancer Agents

“…They are among the most extensively investigated compounds by biochemists and medicinal chemists. 6 Thiazolidinones in particular show interesting anticancer, 7 anti-HIV, 8 tuberculostatic, 9 antihistaminic, 10 anticonvulsant, 11 antibacterial, 12 and anti arrhythmic 13 activities. So called hybrid molecules have been shown to be highly active and effective in medicinal chemistry.…”

Synthesis and <i>In Vitro </i> Antimicrobial Activity of 3-(5-((2-Oxo-2<i>H</i>-Chromen-4-yl)Thio)-4-Phenyl-Thiazol-2-yl)-2-Substitutedphenyl Thiazolidin-4-One

“…Thiazolidine-4-ones and it derivatives possess some important biological activities and pharmacological properties such as anti-inflammatory [4], antitubercular [5], anticancer [6,7], antitumor [8], anti-HIV [9], antibacterial [10], antifungal [11], antioxidant [12], antiviral [13], anticonvulsant [14], nematicidal [15], antihistaminic [16], anti YFV (yellow fever virus) [17] activity etc.…”