Synthesis and antifungal activity of benzofuran-5-ols

Synthesis and Antifungal Activity of Derivatives of 2- and 3-Benzofurancarboxylic Acids

“…1), may act as inhibitors of fungal N-myristoyltransferase, thereby giving them antifungal activity (Masubuchi et al, 2001Ebiike et al, 2002;Georgopapadakou, 2002;Kawasaki et al, 2003). Benzofurans substituted at C-5 with OH have more recently been shown to have antifungal activity (Ryu et al, 2010). Finally, research by Kossakowski et al (2010) presents data on halogenated derivatives of 3-benzofurancarboxylic acids.…”

Synthesis, Characterization, and Antibacterial Activity of Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II) Complexes of Schiff's Base Type Ligands Containing Benzofuran Moiety

“…Among them, benzofuran based fused heterocycles have been of great interest as they are abundant in nature and have wide pharmacological activities [8]. Benzofuran based compounds have been reported to show activities as anti-infective agents, like antifungal [9][10][11][12], antiprotozoal, and antitubercular [13][14][15], and also in the treatment of antiarrhythmic [16] and cardiovascular [17] diseases. According to the literature survey in the recent years, there has been an increased interest investigation of anti-microbacterial activities on benzofuran derivatives, especially 2-substituted [18] or 2,3-disubstituted benzofurans derivatives [19].…”

A Facial Protocol for the Synthesis of Benzofuran Derivatives by the Reaction of o-Hydroxy Aryl Ketone, Amine and Chloroacetyl Chloride

“…Substituted benzofurans are pharmaceutically important heterocycles that display numerous biological activities such as antimicrobial, 1,2 antifungal, 3 antitubercular, 3,4 antiprotozoal, 5 anti-HIV-1, anticancer, 6,7 antimalarial, 7 antiretroviral, 8 antioxidant, 9 cytotoxic, 10 anticonvulsant, 11 anti-inflammatory 12 activities. They have also been exhibited some properties as steroidogenic inhibitors, 13 …”

“…Representative Procedure for the Synthesis of Substituted Acetamide (5). The solution of o-hydroxy aryl ketone 4 (5.0 mmol, 1.0 equiv), K 2 CO 3 (6.0 mmol, 1.2 equiv), N-substituted-2-chloroacetamide 3 (5.0 mmol, 1.0 equiv) in CH 3 CN (10 mL) was refluxed and monitored by TLC.…”