Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives

Georgey, Hanan H.; Abdelgawad, Nagwa M.; Abbas, Samir Y.

doi:10.3390/molecules13102557

Cited by 95 publications

(76 citation statements)

References 20 publications

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“…Quinazolinone and its derivatives are considered to be important heterocyclic skeleton with extended biological activities, such as antihypertensive [13,14], antimicrobial [15,16], antihyperlipidemic [17,18], anti-inflammatory [19,20], and anticonvulsant [21][22][23][24][25] activities. Meanwhile, some of their derivatives are used as antitumor chemotherapeutic agents [26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

An environmentally friendly approach for the synthesis of quinazolinone sulfonamide

et al. 2017

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Section: Introductionmentioning

confidence: 99%

An environmentally friendly approach for the synthesis of quinazolinone sulfonamide

et al. 2017

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“…It has been reported as antimicrobial [1e7], antiviral [8], anti-HIV [9], anticonvulsant [10,11], antiinflammatory [12e14], antihistaminic [15], anti-tubercular [16,17], and anticancer [18,19] activity, etc. A huge number of quinazolines had been synthesized and evaluated for various activities however their antiviral activity was not fully investigated to a greater extent.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones

Kumar

Ganguly

Veerasamy

et al. 2010

European Journal of Medicinal Chemistry

219

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A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. Compound 2a showed better antiviral activity against the entire tested virus.

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“…Quinazolin-4-(3H)-one derivatives (43) were showed Anticonvulsant activity [57]. The 3,4-Dihydro-4-oxoquinazolin derivative (44,45) were exhibited anticonvulsant activity [58].…”

Section: Compound 40a-imentioning

confidence: 99%

A Review on a Highly Important Hetrocycle Quinazolinone Compounds and their Diverse Biological Activities

2016

European Reviews of Chemical Research

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Quinazolinone and their derivatives have been studied extensively for various biological activities such as anti-inflammatory, antimicrobial, anticancer, anticonvulsant and anti-HIV activity etc. The purpose of this review was to collate literature work reported by researchers on quinazoline for their various pharmacological activities. Quinazolinone derivatives are one of the most active classes of compounds possessing a wide spectrum of biological activity. Recently several scientists have been reported that introduction of various heterocyclic moieties at quinazolinone nucleus modulate the activity. Various derivatives of quinazolinone have been synthesized and evaluated for their biological activities. This review might be helpful in the development of these novel lead molecules to potential drug candidates for future prospect.Keywords: Quinazoline, antimicrobial, Anti HIV, Anti cancer, biologically active. IntroductionHeterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, heterocyclic structures form the basis of many pharmaceutical, agrochemical and veterinary products. Quinazoline (1) are classes of fused heterocycles that are of considerable interest because of the diverse range of their biological activities such as, antimicrobial, anticancer, anticonvulsant, anti-tubercular, etc [1][2][3][4][5]. Quinazolin is a heterocyclic compound consists of two fused six membered simple aromatic rings, a benzene ring and a pyrimidine ring. The quinazolin nucleus has attracted the attention of medicinal chemists due to its well known anticancer activity, and many substituted quinazolin derivatives have recently earned great interest in chemotherapy as antitumor drugs [6]. Pharmacologically quinazolin particularly quinazolin-4-one (2) or quinazolinone are the most important classes of heterocyclic compounds. Quinazolin-4-one is synthesized when the keto group is introduced in the pyrimidine ring of quinazolin. Quinazolinone compounds possess versatile biological activities; such as anticancer [7][8]

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Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives

Cited by 95 publications

References 20 publications

An environmentally friendly approach for the synthesis of quinazolinone sulfonamide

An environmentally friendly approach for the synthesis of quinazolinone sulfonamide

Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones

A Review on a Highly Important Hetrocycle Quinazolinone Compounds and their Diverse Biological Activities

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