Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones

Abstract

A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. Compound 2a showed better antiviral activity against the entire tested virus.

Synthesis of methyl [3-alkyl-2-(2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamido] alkanoate

“…Anticancer agent Iressa (ZD1839) A is a clinically approved example of quinazoline-based inhibitors which is in phase III clinical trials for cancer used to inhibit the receptor tyrosine kinase of epidermal growth factor. also exhibit pronounced biological activities as antimicrobial, 7,8 anti-HIV (NNRTI), 9,10 anti-tumour, [11][12][13][14][15][16] potential analgesic and anti-inflammatory activity. 17 Non-proteinogenic amino acids are major component in a number of drugs including β-lactam antibiotics 18 and glutamate antagonists.…”

Synthesis and biological evaluation of new hydrazide-Schiff bases

“…These are prepared by condensing primary amines with carbonyl compounds (Dhar and Taploo, 1982). Schiff bases are reported to possess diverse biological and pharmacological actions including potential anti-inflammatory (Gurupadayya et al, 2008), antibacterial (Hearn et al, 2009), antitubercular (Aboul-Fadl et al, 2010) antiviral (Kumar et al, 2010. ), anticonvulsant (Firke et al, 2009), and anthelmintic (Sharma et al, 2009) activities.…”

Design, Synthesis and Biological Activities of Novel Quinazolinone Derivatives Bearing 4-Phenyl-5-thioxo-1,2,4-triazole Mannich Bases

“…喹唑啉酮类衍生物具有优良的生物活性, 已在医药 和农药领域得到了广泛的应用, 如抗肿瘤 [1] 、抗细菌 [2] 、 抗真菌 [3] 、抗疟 [4] 、抗病毒 [5] 等. 目前已商品化的喹唑啉 酮类药物有杀菌剂氟喹唑、抗寄生虫药常山酮、镇静药 物安眠酮和抗癌药物诺拉曲特(图 1)等.…”