Synthesis and anticancer activity of some novel trifluoromethylquinolines carrying a biologically active benzenesulfonamide moiety

Crystal structure of the co-crystalline adduct 4-((4,4-dimethyl-2,6-dioxocyclohexylidene)methylamino)-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide - acetic acid (1/1), C21H24N4O4S ⋅ C2H4O2

“…Additionally, some pyrimidine derivatives exhibited a wide range of biological activity [11]. In obstinacy of our prodigy in the synthesis of capable heterocyclic compounds [12,13], we evidence here the newly synthesized 4-((4, 4-dimethyl-2, 6-dioxocyclohexylidine) methylamino)-N-(4, 6-dimethylpyrimidin-2-yl)benzenesulfonamide.…”

Crystal Structure of 4-(2-chloroacetamido)pyridinium chloride monohydrate, C7H10Cl2N2O2

“…Also, acetamide derivatives have been reported as antitumor activity [5]. Based on the aforementioned and as a continuation for our work to synthesize novel anticancer agents [6][7][8][9][10][11][12], we have designed and synthesized 4-(2-chloroacetamido)pyridinium chloride. …”

Crystal structure of (Z)-4-(4-oxopent-2-en-2-ylamino)benzenesulfonamide, C11H14N2O3S

“…Recently, diaryl sulfone derivatives, that were synthesized from dapson have shown good cytotoxic activity on breast cancer cell line (MCF-7) [9]. As a continuation of our work to design and synthesize novel anticancer agents [6][7][8][9][10][11][12], we have designed and synthesized the title compound. The aim of this work was to design and synthesize of (Z)-4-(4-oxopent-2-en-2-ylamino)benzenesulfonamide having a biologically active sulfonamide moiety.…”

“…Combination of a 4-(4-oxopent-2-en-2-ylamino) sca old with the biologically active sulfonamide moiety has received great attention as PI3 K inhibitor, which is an important enzyme controlling signal transduction [4,[6][7][8]. Recently, diaryl sulfone derivatives, that were synthesized from dapson have shown good cytotoxic activity on breast cancer cell line (MCF-7) [9].…”