Crystal Structure of 4-(2-chloroacetamido)pyridinium chloride monohydrate, C₇H₁₀Cl₂N₂O₂

Abstract

C7H 10 Cl 2 N 2 O 2 , monoclinic, P21/c (no. 14), a = 9.8798(3) Å, CCDC no.: 1481643The crystal structure is shown in the gure. Tables 1 and 2 contain details of the measurement method and a list of the atoms including atomic coordinates and displacement parameters. Source of materialA solution of 4-aminopyridine (0.94 g, 0.01 mol) and 2-chloroacetyl chloride (1.12 g, 0.01 mol) in dry dimethylformamide (10 mL) was stirred for 6 h, then the reaction mixture was poured onto ice/water. The obtained solid was

A Concise Stereoselective Synthesis of (R)‐2‐Benzylmorpholine and ML398 from (R)‐(−)‐2‐Phenylglycinol

“…This hypothesis is consistent with the conformation of the heterocycle observed in the solid state for 3 and 5 ·HCl: due to the presence of the sp 2 ‐hybridized C‐3 atom in 3 , the N atom has a trigonal planar geometry, and the morpholinone adopts a half‐chair conformation , with a puckering amplitude of 0.59(2) Å, favoring the differentiation between α and β faces in the transition state I . Once the alkylation proceeded, and after reduction at C‐3, the chair conformation is restored for the heterocycle in 5 ·HCl, as is observed in the vast majority of morpholinium salts for which X‐ray structures have been determined .…”