Synthesis and anticancer activity of some new s-triazine derivatives

Kumar, Gangasani Jagadeesh; Bomma, H. V. S. Sriramkumar; Srihari, Ejjirothu; Shrivastava, Shweta; Naidu, V.G.M.; Srinivas, K.; Rao, V. Jayathirtha

doi:10.1007/s00044-013-0584-6

Cited by 28 publications

(2 citation statements)

References 44 publications

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“…[ 19 ] The s ‐triazine scaffold due to its symmetrical structure facilitates the synthesis of a diverse set of analogs such as 2‐, 4‐, 6‐mono, di‐ and trisubstituted, symmetrical, and nonsymmetrical compounds bearing different substituents. [ 22 ] Moreover, the reactivity of substituted functional groups on the triazine ring appears to be different. The three chloro substitutions on 2,4,6‐trichloro‐1,3,5‐triazine have been reported to exhibit differential reaction temperature sensitivity for nucleophilic substitutions reactions, thereby facilitating the incorporation of three different nucleophilic fragment groups on the triazine ring.…”

Section: Chemistry Of Triazinesmentioning

confidence: 99%

Potential of triazines in Alzheimer's disease: A versatile privileged scaffold

Gharat

Prabhu

Khambete

2022

Archiv der Pharmazie

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Triazines are six-membered privileged scaffolds that have been explored in drug discovery programs owing to their stability in biological media and robust reactivity.Their unique chemical properties have led to the exploration of the triazinecontaining molecules for multifaceted disorders like Alzheimer's disease (AD). The pathology of AD involves the interplay of multiple biochemical events such as amyloid beta-aggregation, formation of reactive oxygen species, cholinergic degradation, and metal ion dysregulation. The growing incidence of AD, coupled with the limited availability of efficacious medicines, necessitates the identification of newer therapeutic approaches. Privileged scaffolds like triazines with the potential for multiple biological effects offer excellent alternatives to the treatment of multifactorial AD. The present review describes numerous triazine-containing molecules capable of modulating single as well as multiple pathological factors involved in AD.The analysis of structural features of these molecules can provide useful insights for developing newer therapies.

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Section: Chemistry Of Triazinesmentioning

confidence: 99%

Potential of triazines in Alzheimer's disease: A versatile privileged scaffold

Gharat

Prabhu

Khambete

2022

Archiv der Pharmazie

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“…Triazines are an important class of compounds known for a long time due to their versatile activities, such as antifungal [244], anti-HIV [245,246], anti-cancer [247], anti-anxiety [248], anti-tubercular [249], anti-inflammatory [250], and anti-convulsant [251] as well as for their use in industry as reactive dyes [252]. An efficient method for the preparation of biologically active triazine 422 from fatty acid hydrazides 420 and chloroacetamide 421 has been developed by Farshori et al [253] as shown in Scheme 119.…”

Section: Synthesis Of Triazinesmentioning

confidence: 99%

Transition metal-free one-pot synthesis of nitrogen-containing heterocycles

et al. 2015

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One-pot heterocyclic synthesis is an exciting research area as it can open routes for the development of otherwise complex transformations in organic synthesis. Heterocyclic compounds show wide spectrum of applications in medicinal chemistry, chemical biology, and materials science. These heterocycles can be generated very efficiently through highly economical and viable routes using one-pot synthesis. In particular, the metal-free one-pot synthetic protocols are highly fascinating due to several advantages for the industrial production of heterocyclic frameworks. This comprehensive review is devoted to the transition metal-free one-pot synthesis of nitrogen-containing heterocycles from the period 2010-2013.

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New antiproliferative agents derived from tricyclic 3,4‐dihydrobenzo[4,5]imidazo[1,2‐a][1,3,5]triazine scaffold: Synthesis and pharmacological effects

Robello

Salerno

Barresi

et al. 2022

Archiv der Pharmazie

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A series of novel 3,4-dihydrobenzo [4,5]imidazo [1,2-a][1,3,5]triazine (BIT) derivatives were designed and synthesized. In vitro antiproliferative activity was detected toward two human colorectal adenocarcinoma cell lines (CaCo-2 and HT-29) and one human dermal microvascular endothelial cell line (HMVEC-d). The most active compounds, namely 2-4 and 8, were further investigated to clarify the mechanism behind their biological activity. Through immunofluorescence assay, we identified the target of these molecules to be the microtubule cytoskeleton with subsequent formation of dense microtubule accumulation, particularly at the periphery of the cancer cells, as observed in paclitaxel-treated cells. Overall, these results highlight BIT derivatives as robust and feasible candidates deserving to be further developed in the search for novel potent antiproliferative microtubule-targeting agents.

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Synthesis and anticancer activity of some new s-triazine derivatives

Cited by 28 publications

References 44 publications

Potential of triazines in Alzheimer's disease: A versatile privileged scaffold

Potential of triazines in Alzheimer's disease: A versatile privileged scaffold

Transition metal-free one-pot synthesis of nitrogen-containing heterocycles

New antiproliferative agents derived from tricyclic 3,4‐dihydrobenzo[4,5]imidazo[1,2‐a][1,3,5]triazine scaffold: Synthesis and pharmacological effects

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