Synthesis and anticancer activity of [2-hydroxy-1,3-diaminopropane-κ2N,N′] platinum(II) complexes

Antioxidant and anticancer activities of high pressure-assisted extract of longan (Dimocarpus longan Lour.) fruit pericarp

“…Similar results have been reported earlier by Lee et al (2004) where the samples did not inhibit cancer cells but rather increased their growth rate. Our results are also in agreement with those by Liu et al (2008) where SGC 7901 is sensitive to cisplatin treatments, which was confirmed by our results, while the A 549 cell line was resistant to anticancer compounds.…”

Conjugation of Cisplatin Analogues and Cyclooxygenase Inhibitors to Overcome Cisplatin Resistance

“…Anhydrous dichloromethane was purified using an MBRAUN Solvent Purification System MB SPS-800; acetone was dried over molecular sieves (3 Å); pyridine was dried over CaH 2 and distilled under nitrogen atmosphere. Indomethacin and ibuprofen acyl chloride, [49] (2-hydroxy-1,3-diaminopropane-κ 2 N , N ’)-dichloro platinum(II) [PtCl 2 (HO-pda)], [50] (ethane-1,2-diamine)-dichloro platinum(II) [PtCl 2 (en)], [51] ( SP -4-2)-( trans - R , R -cyclohexane-1,2-diamine)-oxalato platinum(II) [Pt(ox)(DACH)], [52] ( SP -4-2)-( trans - R , R -cyclohexane-1,2-diamine)-dihydroxo(oxalato) platinum(IV) [Pt(OH) 2 (ox)(DACH)], [53] and conjugates 3 and 4 [9] were prepared according to the respective published procedures. NMR spectra were recorded on a Bruker AVANCE DRX 400 (400 MHz), a Bruker AVANCE III HD (400 MHz) or a VARIAN Mercury 300 plus (300 MHz) spectrometer; 1 H and 13 C NMR spectra were referenced to tetramethylsilane (TMS) as internal standard; 195 Pt NMR spectra were referenced to Na 2 [PtCl 6 ] as external standard.…”

Platinum(II) oxalato complexes with adenine-based carrier ligands showing significant in vitro antitumor activity

“…Among them, [Pt(dpaOH)X 2 ] complexes (X 2 =2Cl − , ox, malonate, cyclobutane-1,1′-dicarboxylate or 3-hydroxycyclobutane-1,1′-dicarboxylate; dpaOH = 2-hydroxy-1,3-diaminopropane) showed higher in vitro cytotoxicity against the gastric cancer cell line (SGC-7901), human prostate cancer cell line (LNcap) cancer cells and both sensitive and resistant human lung cancer cell line (A549 and A549/ATCC) as compared to carboplatin [17]. The complex trans-[Pt(tce) 2 (pta) 2 ], involving the thiocarbamate ester of the SC (OMe)= NC 6 H 4 Cl composition (tce) and 1,3,5-triaza-7-phosphaadamantane (pta), was determined to be more active than cisplatin against human ovarian carcinoma cells (SK-OV-3) and human colon carcinoma (HT29) [18].…”