Synthesis and anticancer activities of a novel class of mono- and di-metallic Pt(<scp>ii</scp>)(salicylaldiminato)(DMSO or Picolino)Cl complexes

Rahman, Faiz-Ur; Ali, Amjad; Guo, Rong; Zhang, Yunchang; Wang, Hui; Li, Zhan‐Ting; Zhang, Dan‐Wei

doi:10.1039/c4dt03018d

Cited by 37 publications

(18 citation statements)

References 58 publications

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“…A slight distortion from planarity is indicated with a dihedral angle of 4.39 (11) between the Cl2-Pt1-S1 and Cl1-Pt1-N1 planes. The Pt1-N1, 2.081 (3) Å , Pt1-S1, 2.2206 (10) Å , and the two Pt-Cl bond distances Pt1-Cl1 2.2894 (11) Å , and 2.2933 (11) Å are normal and comparable to values reported for related Pt II complexes in the literature (Francisco et al, 2011;Rahman et al 2015;Huo et al 2011).…”

Section: Structure Descriptionsupporting

confidence: 84%

trans-(Aniline-κN)dichlorido(dimethyl sulfoxide-κS)platinum(II)

Wang

Yuan

2018

IUCr Data

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Section: Structure Descriptionsupporting

confidence: 84%

trans-(Aniline-κN)dichlorido(dimethyl sulfoxide-κS)platinum(II)

Wang

Yuan

2018

IUCr Data

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“…According to the classical Stern–Volmer equation: I 0 / I = 1 + K sq r , where I 0 and I represent the fluorescence intensities in the absence and presence of complexes, respectively, r is the concentration ratio of complex to DNA and K sq is a linear Stern–Volmer quenching constant dependent on the ratio of concentration of bound EtBr to concentration of DNA . The K sq value is obtained as the slope of a linear plot of I 0 / I versus r .…”

Section: Resultsmentioning

confidence: 99%

Two Ho(III) and Co(II) complexes constructed from bis(triazol‐1‐yl)benzoic acid with structurally similar carboxyl ligands: Syntheses, structures and biological activities

Zhu

Wang

Meng

et al. 2018

Applied Organom Chemis

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Two new complexes, [Ho(L) 2 NO 3 ] n (1) and [Co(L′) 2 Cl 4 ] n (2) (HL = 3,5bis(triazol-1-yl)benzoic acid, HL′ = 2,4-bis(triazol-1-yl)benzoic acid), have been synthesized and characterized. Interactions with DNA through absorption titration experiments, fluorescence spectra, viscosity measurements and a molecular docking study were examined. The results suggested that complexes 1 and 2 interact with DNA in a partial intercalation mode. DNA binding affinity was determined using k b values, which indicated that the binding activity of the complexes to DNA was complex 2 (k b = 1.93 × 10 4 ) > complex 1 (k b = 1.06 × 10 4 ). Gel electrophoresis assay demonstrated that the complexes have the ability to cleave pBR322 DNA. Apoptotic assay indicated that the complexes can induce programmed death of Hela cells (human cervix carcinoma cells). A cytotoxicity study indicated that complex 2 shows a greater inhibitory rate of Hela cells than complex 1 and the cytotoxicity of both 1 and 2 showed time dependence. Especially, the efficacy of complex 2 was shown to be higher than that of cisplatin at 72 h.

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“…Cancer is a broad term to describe a disease that characterized by the uncontrolled proliferation of cells resulting from the disruption or dysfunction of regulatory signaling pathways that Molecular Docking are normally under tight control [20,21]. In modern life, cancer is one of the big health killers.…”

Section: Morpholine Hydrazone Scaffold: Synthesis Anticancer Activitmentioning

confidence: 99%

Molecular Docking Studies of Enzyme Inhibitors and Cytotoxic Chemical Entities

Sultan¹,

Singh²,

Ashraf³

et al. 2018

Molecular Docking

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Docking is a powerful approach to perform virtual screening on large library of compounds, rank the conformations using a scoring function, and propose structural hypotheses of how the ligands inhibit the target, which is invaluable in lead optimization. Using experimentally proven active compounds, detailed docking studies were performed to determine the mechanism of molecular interaction and its binding mode in the active site of the modeled yeast α-glucosidase and human intestinal maltase-glucoamylase. All active ligands were found to have greater binding affinity with the yeast α-glucosidase as compared to that of human homologs, intestinal, and pancreatic maltase, by an average value of~À1.3 and~À0.8 kcal/ mol, respectively. Thirty quinoline derivatives have been synthesized and evaluated against β-glucuronidase inhibitory potential. Twenty-four analogs, which showed outstanding βglucuronidase activity, have IC 50 values ranging between 2.11 AE 0.05 and 46.14 AE 0.95 μM than standard D-saccharic acid 1,4-lactone (IC 50 = 48.4 AE 1.25 μM). Structure activity relationship and the interaction of the active compounds and enzyme active site with the help of docking studies were established. In addition, Small series of morpholine hydrazones synthesized to form morpholine hydrazones scaffold. The in vitro anti-cancer potential of all these compounds were checked against human cancer cell lines such as HepG2 (Human hepatocellular liver carcinoma) and MCF-7 (Human breast adenocarcinoma). Molecular docking studies were also performed to understand the binding interaction.

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Synthesis and anticancer activities of a novel class of mono- and di-metallic Pt(ii)(salicylaldiminato)(DMSO or Picolino)Cl complexes

Cited by 37 publications

References 58 publications

trans-(Aniline-κN)dichlorido(dimethyl sulfoxide-κS)platinum(II)

trans-(Aniline-κN)dichlorido(dimethyl sulfoxide-κS)platinum(II)

Two Ho(III) and Co(II) complexes constructed from bis(triazol‐1‐yl)benzoic acid with structurally similar carboxyl ligands: Syntheses, structures and biological activities

Molecular Docking Studies of Enzyme Inhibitors and Cytotoxic Chemical Entities

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