Synthesis and Antibacterial Evaluation of 2- (Substituted Phenylureido) -4-thiocyanatobenzothiazoles

Benzothiazoles from Condensation of o-Aminothiophenoles with Carboxylic Acids and Their Derivatives: A Review

“…The same authors used PPA in the condensation of substituted o-ATP with substituted 4-aminobenzoic acids at 220 • C to synthesize the 2-(p-aminophenyl)BTs 6a (Scheme 2) to be evaluated against breast cancer cell lines in vitro and in vivo [46]. ATP was condensed with substituted 4-aminobenzoic acids in PPA to give the 2-substitutedBTs 6b-d (Scheme 2).…”

“…Moreover, the BT moiety is also found in many functional molecules, such as ratiometric fluorescent pH indicators and ligands for catalytic reactions [18,19]. Since 1991, BT has been a moiety known to play an important role in chemistry, biochemistry, and medicinal chemistry, with a wide array of interesting biological activities and therapeutic functions, such as antimicrobial [20][21][22][23], anticancer [24][25][26][27][28][29], anthelmintic [30], antidiabetic [31,32], antituberculotic [33,34], antitumor [35][36][37][38][39][40][41], antitrypanosomal [42], antiviral [43][44][45], antibacterial [46][47][48][49], antioxidant [50], antiglutamate and antiparkinsonism [51,52], analgesic [53], anti-inflammatory [54,55], antifungal [56,57], antileishmanial [58], anticonvulsant [59], neuroprotective [60], muscle relaxant [61], vasodilator…”

Recent Advances in Synthesis of Benzothiazole Compounds Related to Green Chemistry

“…The benzothiazole ring system was originally found in various marine and terrestrial natural compounds, which is widely used as vulcanization accelerators, antioxidants, plant growth regulators, anti-inflammatory agents, enzyme inhibitors, imaging reagents, fluorescence materials, and electroluminescent devices due to its highly pharmaceutical and biological activity [1][2][3][4]. Especially, benzothiazole plays an important role in the field of medicinal chemistry and renders an extensive range of biological activities including anti-cancer [5,6], anti-bacterial [7,8], anti-tuberculosis [9,10], anti-diabetic [11], anthelmintic [12], anti-tumor [13][14][15], anti-viral [16,17], anti-oxidant [18], anti-inflammatory [19,20], anti-glutamate and anti-parkinsonism [21], anticonvulsant [22], muscle relaxant activities [23], neuroprotective [24], inhibitors of several enzymes and so on [25]. Hence, the synthesis of benzothiazoles is of considerable interest due to their potent and significant biological activities and great pharmaceutical value.…”

Recent advances in the synthesis of 2-substituted benzothiazoles: a review

“…1). 6 The benzothiazole moiety plays an important role in chemistry and is also present in a variety of biologically active applications such as anti-microbial, [7][8][9][10] anti-cancer, [11][12][13][14][15][16] anthelmintic, 17 anti-diabetic, 18,19 anti-tuberculotic, 13,20,21 antitumor, [22][23][24][25][26][27][28] anti-trypanosomal, 29 anti-viral, [30][31][32] antibacterial, [33][34][35][36] anti-oxidant, 37 anti-glutamate and anti-parkinsonism, 38,39 analgesic, 40 anti-inammatory, [41][42][43] antifungal, 44,45 antileishmanial, 46 anticonvulsant, 47 neuroprotective, 48 muscle relaxant activities, 49 vasodilator, 50 orexin receptor,…”