Recent advances in the synthesis of 2-substituted benzothiazoles: a review

Abstract

Recent advances in various synthetic protocols of 2-substituted benzothiazole derivatives.

Synthesis and anti-oomycete activity of novel quinazolin- and benzothiazol-6-yloxyacetamides: Potent aza-analogs and five-ring analogs of quinoline fungicides

“…This standard 2-aminobenzothiazole synthesis proceeds via an ortho-thiocyanato-aniline intermediate, which undergoes ring closure by reaction with bromine. [16][17][18] For the following deamination we applied Chedekel's conditions 19,20 with sodium nitrite and phosphinic acid. The ether cleavage of the resulting methoxy-substituted benzothiazole 25 delivered the desired 4-chloro-6-hydroxybenzothiazole 26.…”

Efficient sodium bisulfite-catalyzed synthesis of benzothiazoles and their potential as ureases inhibitors

“…1) exhibit excellent in vitro antifungal activities. 2,12 Among them, two main methodologies have been widely explored for the synthesis of BZTs. 10 A potent inhibitory effect on the ureolytic activity of urease was reported for 2-aminobenzothiazole (BZT-III), exhibiting an IC 50 value of 28.88 mg mL À1 (79.7 mM) under the tested experimental conditions.…”

“…Additionally, in vivo assays disclosed that BZT-I is more effective than the commercial antifungal kresoxim-methyl against Sphaerotheca fuliginea and Pseudoperoniospora cubensis. 12,13 The rst one is based on the direct reaction of 2-aminothiophenol with aldehydes, ketones, halides or carboxylic acids and derivatives; this is the most used approach for the preparation of BZTs since it develops with no need of sequential multistep reactions to prepare starting materials. 11 Several methods were developed for preparing benzofused heterocycles.…”

The Beneficial Sinergy of MW Irradiation and Ionic Liquids in Catalysis of Organic Reactions

“…Thus, it is not surprising that the synthesis of key rings has been explored in terms of sustainability, as well illustrated in 2014 reviews discussing alternative reaction methods for the synthesis of quinoline [127] and benzothiazole [128] derivatives, including syntheses promoted by microwave or ultrasound, recyclable and reusable catalysts, non-volatile solvents as ILs, or solvent-free conditions.…”