Synthesis and Antibacterial Evaluation of Tetrahydropyrimidine-5-carboxamide

Abstract

A series of new dihydropyrimidine-2H-ones/thiones were synthesized and evaluated in vitro for their antibacterial activity. Characterization of newly synthesized dihydropyrimidones was done by physical and spectral data. All the synthesized compounds were evaluated for their antibacterial activity. Amongst all, compounds 3e and 4e registered high activity against the bacterial strain when compared to standard drug.

Design, synthesis and evaluation of cytotoxic, antimicrobial, and anti-HIV-1 activities of new 1,2,3,4-tetrahydropyrimidine derivatives

“…From the viewpoint of structure activity relationship, we wanted to establish the effect of structural changes on the cytotoxic, anti-bacterial and anti-HIV activities within this group of compounds by comparing the activity of those bearing an aromatic substituent at C4 and C5, a carbonyle moiety at C2 and two hydrogen atoms at N1 and N3 positions. Structure activity relationships of previous researches have shown that presence of aromatic moieties such as substituted phenyls and hetroaromatic rings at C4 position could enhance their cytotoxicity, antimicrobial, and anti-HIV effects compared to aliphatic groups (18192021222324252627).…”

“…There is no report for cytotoxic activity against MCF-7 and HeLa cell lines by 1,2,3,4-tetrahydropyrimidines with benzyestre and hydrogen at C-5 and N-1 moieties, respectively. Additionally, several reports of antimicrobial activities of substituted 1,2,3,4- tetrahydropyrimidines have been published in the recent years (162425). These derivatives with different groups at C-2, C-4 and C-5 positions, were screened against diverse Gram negative and Gram positive microorganisms and showed moderate to excellent antimicrobial activities (21).…”

Synthesis of poly-tetrahydropyrimidine antibacterial polymers and research of their basic properties

“…[11][12][13][14] Pyrimidine compounds have several interacting functional groups, which determine their strong biological activity. 15,16 There are various substituted compounds and derivatives of pyrimidine rings in nature, including nucleotides, thiamine, and tetrahydropyrimidines. 17 Pyrimidine derivatives such as uric acid have been known as early as the nineteenth century.…”