Synthesis of poly-tetrahydropyrimidine antibacterial polymers and research of their basic properties

Xu, Taimin; Li, Wenlong; Zhang, Rong; Guo, Shuaibing; Yu, Bing; Cong, Hailin; Shen, Youqing

doi:10.1039/d1bm01465j

Cited by 9 publications

(7 citation statements)

References 38 publications

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“…21 As biomedical materials, antimicrobial peptides not only have excellent antibacterial properties, but also play an important role in cytotoxicity to normal cells. 22,23 First, we placed 3T3 cells in 96-well plates, cultured them for 24 hours, until the cells covered the well plate, and then sucked out the upper liquid, added a series of pre-configured concentrations of antimicrobial peptide solution to the well plate, and set up the control group. The cell activity was tested by the MTT assay and live-death staining assay.…”

Section: Cytotoxicity Testmentioning

confidence: 99%

Screening of a short chain antimicrobial peptide-FWKFK and its application in wound healing

et al. 2023

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Section: Cytotoxicity Testmentioning

confidence: 99%

Screening of a short chain antimicrobial peptide-FWKFK and its application in wound healing

et al. 2023

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“…Pyrimidines are six-membered nitrogen heterocyclic compounds widely used in medicine. They have extensive biological activities and have remarkable effects in the treatment of inflammation, malaria, and cancer . In recent years, pyrimidine derivatives have attracted more and more attention because of their high efficiency and low toxicity, especially tetrahydropyrimidine (THP) compounds have Schiff bases and have better biological activity.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Application of High-Efficiency, Antibacterial, and Antiviral PET–PTHP Fibers

He,

Shi,

et al. 2023

ACS Appl. Mater. Interfaces

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Transmission through the respiratory tract is one of the most important ways for bacteria and viruses to infect the human body; the use of high-performance antibacterial and antiviral protective equipment is the most effective way to prevent the spread of respiratory diseases. However, at present, most personal protective equipment lacks the ability to kill pathogens. In this paper, a kind of polytetrahydropyrimidine−polyethylene terephthalate functional fiber (PET−PTHP fibers) with highly sustained antibacterial and antiviral properties was prepared. The inactivation rate of the fibers against Staphylococcus aureus and Escherichia coli was as high as 99.99%, and the antibacterial time was more than 72 h. The fibers have an obvious destructive effect on lentiviruses and can reduce the infection rate of lentiviruses in BxPC-3 cells from 25.4 to 9.7%. The cytotoxicity test, cell live/dead staining test, and cell proliferation test all confirmed that PET−PTHP fibers have no obvious cytotoxicity and good cytocompatibility. By applying the functional fibers to the inner layer of the masks, a new type of mask with adsorption, filtration, and killing properties against pathogens was prepared. The filtration efficiency of the new masks was 99.3%, and the pressure drop was 104 Pa. The new masks have excellent air permeability and filtration effect, meet the practical application conditions, and are of grade A; therefore, these masks provide medical protection as well as kill pathogens at the same time, further reducing the risk of human infection.

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“…Numerous pyrimidine medicines have a range of therapeutic properties like anticancer such as 5-fluorouracil (5-FU), antiviral such as Idoxuridine and Trifluridine, anti-HIV such as Zidovudine and Stavudine, antibacterial such as Trimethoprim, Sulphamethiazine, and Sulphadiazine, antihypertensive such as Minoxidil and Prazosin, antithyroid such as Propylthiouracil, and antibiotic such as Bacimethrine [ 20 ]. Pyrimidine is a crucial component of nucleic acids, and it is used in pharmaceutics as a building block for the synthesis of anti-inflammatory, anti-hypertensive, antioxidant, anti-SARS [ 21 , 22 , 23 ], antiviral [ 24 ], anticancer [ 25 ], and antibacterial agents [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Novel 2-Thiouracil-5-Sulfonamide Derivatives: Design, Synthesis, Molecular Docking, and Biological Evaluation as Antioxidants with 15-LOX Inhibition

et al. 2023

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New antioxidant agents are urgently required to combat oxidative stress, which is linked to the emergence of serious diseases. In an effort to discover potent antioxidant agents, a novel series of 2-thiouracil-5-sulfonamides (4–9) were designed and synthesized. In line with this approach, our target new compounds were prepared from methyl ketone derivative 3, which was used as a blocking unit for further synthesis of a novel series of chalcone derivatives 4a–d, thiosemicarbazone derivatives 5a–d, pyridine derivatives 6a–d and 7a–d, bromo acetyl derivative 8, and thiazole derivatives 9a–d. All compounds were evaluated as antioxidants against 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydrogen peroxide (H2O2), lipid peroxidation, and 15-lipoxygenase (15-LOX) inhibition activity. Compounds 5c, 6d, 7d, 9b, 9c, and 9d demonstrated significant RSA in all three techniques in comparison with ascorbic acid and 15-LOX inhibitory effectiveness using quercetin as a standard. Molecular docking of compound 9b endorsed its proper binding at the active site pocket of the human 15-LOX which explains its potent antioxidant activity in comparison with standard ascorbic acid.

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Synthesis of poly-tetrahydropyrimidine antibacterial polymers and research of their basic properties

Abstract: Modern medicine has increasingly higher requirements for antibacterial materials. In order to overcome this challenge, we use alkynyl monomers, amino monomers, formaldehyde, and acetic acid as raw materials to synthesize...

Cited by 9 publications

References 38 publications

Screening of a short chain antimicrobial peptide-FWKFK and its application in wound healing

Screening of a short chain antimicrobial peptide-FWKFK and its application in wound healing

Preparation and Application of High-Efficiency, Antibacterial, and Antiviral PET–PTHP Fibers

Novel 2-Thiouracil-5-Sulfonamide Derivatives: Design, Synthesis, Molecular Docking, and Biological Evaluation as Antioxidants with 15-LOX Inhibition

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