Synthesis and antibacterial evaluation of new heterocyclic system: [1,2,4]triazolo[3′,4′:6,1]pyridazino[4,3-e][1,3,4]thiadiazine

Abstract

A series of 1,2,4-triazolo[3′,4′:6,1]pyridazino[4,3-e][1,3,4]thiadiazines have been synthesized by intermolecular cycli­zation of a hydrazide derivative with various triethyl ortho­esters. The antibacterial activity of various derivatives of this new heterocyclic system was evaluated.

Synthesis of [1,2,4]Triazolo[3,4-b]Pteridines as a Novel Class of Heterocyclic Compounds

“…Also, the 1 H NMR spectrum of compound (5d) revealed two distinguished D 2 O-exchangeable signals at δ 3.84 and 5.68 ppm assignable to NH 2 and NH moieties, respectively, which were removed on being occurrence of fused triazole moiety in product (6d). The molecular ion peak of compound (6d) which was observed at m/z 294 (M+) together with the result of micro analytical data fully support the molecular formula of C 15 …”

“…[8][9][10][11][12][13] Encouraged by these reports and in continuation of our interest in the synthesis of a variety of heterocyclic systems as biologically active compounds, [14][15][16][17] we describe here a facile synthesis and structural elucidation of some new [1,2,4]triazolo [3,4-b] pteridine derivatives as a novel heterocyclic system.…”

Synthesis and Antioxidant Evaluation of Quinoxalino[2′,3′:5,6][1,3,4]thiadiazino[2,3‐b]quinazolin‐15‐ones: Derivatives of a Novel Ring System

“…Obviously, combination of two or more moieties into one can result in discovery of new bioactive molecules with improved biological activities. In this regard and in continuation of our previous research in this field , we wish to report the combination of quinazoline and quinoxaline moieties via formation of a thiadiazine core to afford a novel pentacyclic ring system. Antioxidant activity of the new system and its derivatives was evaluated.…”

Synthesis of New Pyrimido[4,5‐e][1,2,4]triazolo[3,4‐b][1,3,4]thiadiazine Derivatives via S/N Smiles Rearrangement

“…Based on these findings and in continuation of our studies on the synthesis of potentially bioactive heterocyclic compounds , we wish to report on the synthesis and regiochemistry of new pyrimido[4,5‐ e ][1,2,4]triazolo[3,4‐ b ][1,3,4]thiadiazine derivatives.…”