Synthesis and antibacterial and antiviral activities of myricetin derivatives containing a 1,2,4-triazole Schiff base

Abstract

The myricetin derivatives containing a 1,2,4-triazole Schiff base were designed and synthesized. Antibacterial mechanism was investigated through SEM.

Synthesis and antibacterial activity of novel myricetin derivatives containing sulfonylpiperazine

“…As shown in Scheme 1, intermediate 1 and 2 were prepared via the reported methods (Chen et al 2019). Myricetrin (1 mmol) and methyl iodide (15 mmol) were stirred 43 °C for 48 h, and then suction filtration and the filter was extracted with CH 2 Cl 2 , most of the solvent in the filtrate was removed by spin evaporation and hydrochloric acid (10 mL) was added under reflux in the ethanol to obtain the intermediate 1.…”

“…Meanwile, some myricetin derivatives containing piperazine amide also showed good anticancer activity (Ruan et al 2018a, b). And there were also reported some agricultural antibacterial activities of myricetin derivatives (Li et al 2019;Chen et al 2019;Jiang et al 2020a, b). At the cellular level, chalcone containing myricetin can be influenced by inhibiting the differentiation of Gaoyou duck embryonic osteoclasts in vitro (Fu et al 2019).…”

Crystal Structure and Solid-State Properties of Metal Complexes of the Schiff Base Ligands Derived from Diacetylmonoxime: A Brief Review

“…From the Arrhenius plots (Figure 27), the electronic parameters, i.e., activation energy of electrical conduction (E a ) and the energy gap for directly allowed transitions of metal complexes (2) and (8)(9)(10)(11), are calculated, and the results obtained are summarized in Table 3.…”

“…But the importance of Schiff base ligands in several fields compelled us to consider it as a "privileged ligand" even in recent days [1,2]. Currently, there has been considerable interest in the chemistry of Schiff base metal complexes, primarily because of their tremendous biochemical activity, viz., antibacterial [3,4], antimalarial [5,6], antiviral [7,8], and antitumor activities [9][10][11]. Besides, some transition metal Schiff base complexes were found to be efficient catalysts in organic synthesis [12][13][14][15][16][17][18].…”

Electrochemical and spectroscopic characterization of biologically important Schiff bases

“…1,2,4-triazoles are the subject of extensive investigations because of their various clinical, industrial, and agricultural applications. Triazoles are bestowed with extensive biological activities including antibacterial [17][18][19], anti-fungal [20], anti-viral [21][22], anti-cancer [23][24][25], anti-microbial, anti-tumour and cytotoxic activities [26][27]. Their biological applications are generally found to be related with their oxidation potential [28] that entails the transfer of a hydrogen atom through a proton coupled electron transfer reaction.…”