Synthesis and antibacterial activity studies of 2,4-di substituted furan derivatives

Malladi, Sireesha; Nadh, R. Venkata; Babu, K. Suresh; Babu, P. Suri

doi:10.1016/j.bjbas.2017.08.001

Cited by 22 publications

(15 citation statements)

References 31 publications

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“…To the best of our knowledge, compound 1 is furanoid toxin, which had been isolated from Curvularia lunata, the pathogen that causes Curvularia leaf spot on maize [11]. This compound has been synthesized and shown antibacterial activity with MIC value of 100 μg/ml against Streptococcus pyogenes, Proteus vulgari, and E. coli [15]. In this study, compound 1 exhibited better antibacterial activity especially towards S. aureus ATCC 25923 with MIC…”

Section: Discussionmentioning

confidence: 84%

Streptomyces zerumbet, a Novel Species from Zingiber zerumbet (L.) Smith and Isolation of Its Bioactive Compounds

Taechowisan¹,

Puckdee²,

Phutdhawong³

2019

AiM

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Streptomyces zerumbet W14, a novel species of the endophyte genus Streptomyces was isolated from the rhizome tissue of Zingiber zerumbet (L.) Smith. Identification of strain W14 was based on its morphology, chemotaxonomy and phylogenetic analysis using 16S rDNA sequence. It was classified as the secondary meabolites of the culture extract were studied. The major active ingredients from the crude extract were purified by silica gel column chromatography and identified by spectroscopic data. The crude extract and purified compounds were tested for their biological activities on antibacterial and anti-inflammatory properties. The crude extract showed inhibition on the growth of Gram-positive bacteria with the MIC and MBC values of 8-32 µg/ml and 32-128 µg/ml, respectively. The isolated compounds were identified to be methyl 5-(hydroxymethyl)furan-2-carboxylate (1) and geldanamycin (2). Bioassay studies showed that compound 1 had antibacterial activity against Staphylococus aureus ATCC 25923 and Methicillin Resistant S. aureus strain Sp6 (clinical isolate) with the MIC and MBC values of 1 µg/ml and 16-64 µg/ml, respectively, and also showed activity against Bacillus Calmette-Guérin (vaccine strain) with MIC and MBC values of 128.00 µg/ml and 128.00 µg/ml, respectively. The compound 2 at the concentration of 1-5 µg/ml had in vitro anti-inflammatory activity on LPS-induced RAW 264.7 cells by inhibition of mRNA expression and production of inducible NO synthase (iNOS), tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). These results suggest that compounds 1 and 2 produced by S. zerumbet W14 (an endophyte of Z. Zerumbet) have antibacterial and anti-inflammatory activities, respectively. Therefore, the future studies on these compounds could be useful for the management of bacterial infections and inflammatory diseases.

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Section: Discussionmentioning

confidence: 84%

Streptomyces zerumbet, a Novel Species from Zingiber zerumbet (L.) Smith and Isolation of Its Bioactive Compounds

Taechowisan¹,

Puckdee²,

Phutdhawong³

2019

AiM

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“…Enthusiastic researchers in this field can extend their investigation in relating the pharmacological activities exhibited by Caralluma species to their corresponding phytochemicals such as flavone glycoside, luteoline-4 ' -Oneohesperiodoside, [21] pregnane glycosides, [101,118] acylated pregnane glycosides, [119] acylated steroidal glycosides, [115] and pregnane steroid. [120,121] Advancement of new routes [122][123][124][125] and novel approaches [126][127][128][129][130][131][132][133] of synthesis are helping the synthesis of molecules of therapeutic importance. However, researchers are striving further due to resistance gained by strains toward these drugs.…”

Section: Phytochemical and Pharmacological Activitiesmentioning

confidence: 99%

Untitled

Nadh¹

2018

AJP

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In history, medicinal plants were proven as a source of active compounds with therapeutic applications, and at present, they are an important collection for the discovery of novel drug leads. Caralluma is a genus used as traditional medicine. The present article thoroughly reviewed about the classification of Caralluma into subgenera, number of its species, its distribution in different parts of the world, and pharmacological activities exhibited by different species of Caralluma.

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“…The minimum inhibitory concentration of compound 3f(4-{[(E)-(3-Phenyl-1H-pyridazol-4-yl)methylidene]-amino}-4H-1,2,4-triazole-3-thiol) against S. aureus, B. subtilis, E. coli, P. aeruginosa is 3 times lower than the concentration of Ceftriaxon of 1.6125 mg/mL (Malladi et al, 2017).…”

Section: Introductionmentioning

confidence: 96%

Determination of antimicrobial activity of some 1,2,4-triazole derivatives

Al-Rawashdeh

2018

Regul. Mech. Biosyst.

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We carried out MIC of the derivatives of 1,2,4-triazole II (4-((5-nitrofuran-2-yl)methyleneamino)-1-propyl-4H-1,2,4-triazolium bromide) and I (N-((5-nitrofuran-2-yl)methylene)-4H-4-amino-1,2,4-triazolidium chloride) against Escherichia coli ATCC 3912/4 and E. coli k88ad, Staphylococcus aureus ATCC 25923 and S. aureus k99, Klebsiella pneumonia k56 and Salmonella typhimurium 144, S. enteritidis. All test cultures were sensitive to compound II at concentrations of 1,25-0,039 μg/ml. Similar MIC (0,039 μg/ml) of compounds II and I were set for E. coli k88a and S. aureus k99 test cultures -0,156 μg/ml. Only S. aureus ATCC 25923 and K. pneumonia k56 had sensitivity to ceftriaxone (MIC = 0,097 μg/ml). Antiviral activity of Trifuzol (piperidine 2-[5-(furan-2-il)-4-phenil-1,2,4-triazol-3ilthio]acetate) and avistim (morpholines 3-(4-pyridyl)-1,2,4-triazolil-5-thioacetate) against the chicken infectious bronchitis virus (VIB) strain 4/91 was characterized by a decrease in mortality and pathological changes of chicken embryos (CE) which were induced by the virus. Death of infected CE provoked by the strain 4/91 of VIB in dilution 10 -3 occurred at 57.1%. The reduction in the percentage of deaths of CE infected by the virus in dilution 10 -3 in the presence of Avistim was 28.6%, and with Trifuzol 14.3%. The use of avistim and Trifuzol compounds reduced VIB infectious activity when it was cultivated in CE, reducing the titre of the virus (strain 4/91) by 3 lg EID 50 cm -3 .

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Synthesis and antibacterial activity studies of 2,4-di substituted furan derivatives

Cited by 22 publications

References 31 publications

<i>Streptomyces zerumbet</i>, a Novel Species from <i>Zingiber zerumbet</i> (L.) Smith and Isolation of Its Bioactive Compounds

<i>Streptomyces zerumbet</i>, a Novel Species from <i>Zingiber zerumbet</i> (L.) Smith and Isolation of Its Bioactive Compounds

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Determination of antimicrobial activity of some 1,2,4-triazole derivatives

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Synthesis and antibacterial activity studies of 2,4-di substituted furan derivatives

Cited by 22 publications

References 31 publications

&lt;i&gt;Streptomyces zerumbet&lt;/i&gt;, a Novel Species from &lt;i&gt;Zingiber zerumbet&lt;/i&gt; (L.) Smith and Isolation of Its Bioactive Compounds

&lt;i&gt;Streptomyces zerumbet&lt;/i&gt;, a Novel Species from &lt;i&gt;Zingiber zerumbet&lt;/i&gt; (L.) Smith and Isolation of Its Bioactive Compounds

Untitled

Determination of antimicrobial activity of some 1,2,4-triazole derivatives

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<i>Streptomyces zerumbet</i>, a Novel Species from <i>Zingiber zerumbet</i> (L.) Smith and Isolation of Its Bioactive Compounds

<i>Streptomyces zerumbet</i>, a Novel Species from <i>Zingiber zerumbet</i> (L.) Smith and Isolation of Its Bioactive Compounds